4.7 Article

Discovery and biological evaluation of tanshinone derivatives as potent dual inhibitors of indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-dioxygenase

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Medicinal

Investigation of chalcogen bioisosteric replacement in a series of heterocyclic inhibitors of tryptophan 2,3-dioxygenase

Arina Kozlova et al.

Summary: This study explored the impact of selenium incorporation in TDO2 inhibitors, demonstrating that chalcogen isosteric replacements can modulate the properties of compounds without disturbing their on-target activity.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

Article Chemistry, Medicinal

Design, synthesis and biological evaluation of exiguamine A analogues as IDO1 inhibitors

Junmin Dong et al.

Summary: Newly synthesized exiguamine A analogues demonstrated potent inhibitory activities against IDO1, with compound 21f showing high selectivity for IDO1 and no cytotoxicity. Further optimization and evaluation of compound 21f is warranted.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Review Biochemistry & Molecular Biology

The ups, downs and new trends of IDO1 inhibitors

Shulun Chen et al.

Summary: Cancer immunotherapy, although showing significant clinical benefits, still falls short of the expected response rates. While some new IDO1 inhibitors have shown promise in preclinical studies, the failure of clinical trials has raised concerns. However, new trends in targeting IDO1 continue to emerge, aiming to bridge the gap between lab research and clinical applications.

BIOORGANIC CHEMISTRY (2021)

Review Chemistry, Medicinal

Diverse chemical space of indoleamine-2,3-dioxygenase 1 (Ido1) inhibitors

Rahul Singh et al.

Summary: IDO1 enzyme catalyzes the initial step of kynurenine pathway and is implicated in immune modulation, antioxidation, and cancer progression. Overexpression of IDO1 plays a pivotal role in immune evasion and cancer development. Research and development of IDO1 inhibitors holds significant potential in immunotherapy and disease treatment.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Discovery of pseudolaric acid A as a new Hsp90 inhibitor uncovers its potential anticancer mechanism

Jiangxin Liu et al.

Summary: The study revealed that Pseudolaric acid A (PAA) exhibits potent antiproliferation and anticancer activities by inducing cell cycle arrest at G2/M phase and promoting cell death through the caspase-8/caspase-3 pathway. PAA was identified as a new Hsp90 inhibitor that directly binds to Hsp90. The research proposed a potential mechanism involving the anticancer activity of PAA and highlighted its potential as a cancer therapy candidate.

BIOORGANIC CHEMISTRY (2021)

Article Chemistry, Medicinal

X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease

Xiang-Li Ning et al.

Summary: This study reported a novel dual hIDO1 and hTDO inhibitor that showed efficacy against clinical symptoms of Parkinson's disease in a mouse model, possibly involving various biological effects.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Chemistry, Medicinal

Design, synthesis and biological evaluation of indole-2-carboxylic acid derivatives as IDO1/TDO dual inhibitors

Guonan Cui et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

Article Chemistry, Multidisciplinary

Facially Amphiphilic Cholic Acid-Lysine Conjugates as Promising Antimicrobials

Poonam Singla et al.

ACS OMEGA (2020)

Article Biochemistry & Molecular Biology

4,6-Substituted-1 H-Indazoles as potent IDO1/TDO dual inhibitors

Lingling Yang et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2019)

Review Immunology

Inhibiting IDO pathways to treat cancer: lessons from the ECHO-301 trial and beyond

Alexander J. Muller et al.

SEMINARS IN IMMUNOPATHOLOGY (2019)

Review Biotechnology & Applied Microbiology

Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

Michael Platten et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Article Chemistry, Medicinal

Inhibition Mechanisms of Indoleamine 2,3-Dioxygenase 1 (IDO1)

Ute F. Rohrig et al.

JOURNAL OF MEDICINAL CHEMISTRY (2019)

Review Oncology

Immune control by amino acid catabolism during tumorigenesis and therapy

Henrique Lemos et al.

NATURE REVIEWS CANCER (2019)

Article Biochemistry & Molecular Biology

Discovery of indoleamine 2,3-dioxygenase inhibitors using machine learning based virtual screening

Hongao Zhang et al.

MEDCHEMCOMM (2018)

Article Chemistry, Medicinal

Design, synthesis and biological evaluation of novel naphthoquinone derivatives as IDO1 inhibitors

Liangkun Pan et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Chemistry, Medicinal

Tryptophan 2,3-dioxygenase inhibitory activities of tryptanthrin derivatives

Shengnan Zhang et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Chemistry, Medicinal

Synthesis of selective 11β-HSD1 inhibitors based on dammarane scaffold

Li-Dong Shao et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)

Review Neurosciences

The kynurenine pathway and the brain: Challenges, controversies and promises

Robert Schwarcz et al.

NEUROPHARMACOLOGY (2017)

Review Multidisciplinary Sciences

Kynurenines: Tryptophan's metabolites in exercise, inflammation, and mental health

Igor Cervenka et al.

SCIENCE (2017)

Article Chemistry, Organic

Site-selective Csp3-H aryloxylation of natural product Tanshinone IIA and its analogues

Bing Liang et al.

TETRAHEDRON LETTERS (2017)

Review Oncology

Discovery of IDO1 Inhibitors: From Bench to Bedside

George C. Prendergast et al.

CANCER RESEARCH (2017)

Article Chemistry, Applied

Design, synthesis, and antimicrobial activities of new tanshinone IIA esters

Lin-Wei Zeng et al.

NATURAL PRODUCT RESEARCH (2016)

Article Toxicology

Cytotoxicity, hemolysis and in vivo acute toxicity of 2-hydroxy-3-anilino-1,4-naphthoquinone derivatives

Valeska Santana de Sena Pereira et al.

TOXICOLOGY REPORTS (2016)

Article Chemistry, Medicinal

Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway

Amy B. Dounay et al.

JOURNAL OF MEDICINAL CHEMISTRY (2015)

Article Chemistry, Organic

Oxygen Insertion of o-Quinone under Catalytic Hydrogenation Conditions

Da-Li Zhang et al.

ORGANIC LETTERS (2013)

Article Chemistry, Medicinal

Design, synthesis and vasodilative activity of tanshinone IIA derivatives

Yue-Feng Bi et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)

Article Chemistry, Medicinal

Rational Design of 4-Aryl-1,2,3-Triazoles for Indoleamine 2,3-Dioxygenase 1 Inhibition

Ute F. Roehrig et al.

JOURNAL OF MEDICINAL CHEMISTRY (2012)

Article Multidisciplinary Sciences

Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase

Luc Pilotte et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

Christiane A. Opitz et al.

NATURE (2011)

Article Chemistry, Medicinal

Synthesis and vasodilative activity of tanshinone IIA derivatives

Yue-Feng Bi et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)

Article Biochemistry & Molecular Biology

Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenase

Christoph F. A. Vogel et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)

Article Chemistry, Medicinal

Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors

Sanjeev Kumar et al.

JOURNAL OF MEDICINAL CHEMISTRY (2008)

Review Medicine, Research & Experimental

Indoleamine 2,3-dioxygenase and tumor-induced tolerance

David H. Munn et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Article Biochemistry & Molecular Biology

Molecules in focus: Indoleamine 2,3-dioxygenase

Nicholas J. C. King et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2007)

Article Multidisciplinary Sciences

Crystal structure of human indoleamine 2,3-dioxygenase:: Catalytic mechanism of O2 incorporation by a heme-containing dioxygenase

H Sugimoto et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Chemistry, Organic

Asymmetric synthesis of 3(S),17-dihydroxytanshinone

JG Zhang et al.

TETRAHEDRON (2004)