☆ 4.7 Article

Design, synthesis and biological evaluations of niclosamide analogues against SARS-CoV-2

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Multidisciplinary Sciences

Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection

Jia-Tsrong Jan et al.

Summary: The COVID-19 pandemic has resulted in over 50 million confirmed cases and more than 1 million deaths globally as of November 2020. Currently, there are no effective antivirals approved by the FDA, posing a major challenge in vaccine development. Alternative treatments are urgently needed.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

添加到收藏夹

Article Chemistry, Medicinal

Application of niclosamide and analogs as small molecule inhibitors of Zika virus and SARS-CoV-2 infection

Khalida Shamim et al.

Summary: Research shows that modifications to the structure of niclosamide can enhance its potential as a treatment for Zika virus and other viral infections. Key analogs are also able to combat the cytopathic effect of SARS-CoV-2 infection.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia

Luca Braga et al.

Summary: COVID-19 patients' lungs contain infected pneumocytes with abnormal morphology and frequent multinucleation, leading to the formation of syncytia driven by the activation of the SARS-CoV-2 spike protein. The antihelminthic drug niclosamide has shown to effectively inhibit cell fusion, potentially providing a new therapeutic approach for COVID-19 disease pathogenesis.

NATURE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Highly accurate protein structure prediction with AlphaFold

John Jumper et al.

Summary: Proteins are essential for life, and accurate prediction of their structures is a crucial research problem. Current experimental methods are time-consuming, highlighting the need for accurate computational approaches to address the gap in structural coverage. Despite recent progress, existing methods fall short of atomic accuracy in protein structure prediction.

NATURE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals

Nils C. Gassen et al.

Summary: Viruses such as SARS-CoV-2 can manipulate cellular metabolism and suppress autophagy, leading to dysregulated immune responses. Studying SARS-CoV-2-infected cells revealed potential host pathways that can be targeted with specific compounds to inhibit virus propagation. This research highlights the importance of understanding host-virus interactions in developing treatment strategies against COVID-19.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Chemistry, Medicinal

Salicylanilides Reduce SARS-CoV-2 Replication and Suppress Induction of Inflammatory Cytokines in a Rodent Model

Steven Blake et al.

Summary: A salicylanilide compound has been identified that can reduce viral loads, modulate key cytokines, and mitigate severe weight loss associated with COVID-19 infections, presenting a promising therapeutic option for combating the disease.

ACS INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Health Care Sciences & Services

A randomized, double-blind, placebo-controlled phase 1 trial of inhaled and intranasal niclosamide: A broad spectrum antiviral candidate for treatment of COVID-19

Vibeke Backer et al.

Summary: UNI91104, a promising candidate for the treatment of COVID-19 and other viral respiratory tract infections, is well-tolerated in healthy volunteers, demonstrating potential for further testing in patient trials.

LANCET REGIONAL HEALTH-EUROPE (2021)

添加到收藏夹

Article Microbiology

Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs

Sangeun Jeon et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann et al.

CELL (2020)

添加到收藏夹

Review Chemistry, Medicinal

Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential

Jimin Xu et al.

ACS INFECTIOUS DISEASES (2020)

添加到收藏夹

Article Medicine, General & Internal

Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial

Yeming Wang et al.

LANCET (2020)

添加到收藏夹

Review Medicine, General & Internal

The COVID-19 Pandemic: A Comprehensive Review of Taxonomy, Genetics, Epidemiology, Diagnosis, Treatment, and Control

Yosra A. Helmy et al.

JOURNAL OF CLINICAL MEDICINE (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Arctigenin, a novel TMEM16A inhibitor for lung adenocarcinoma therapy

Shuai Guo et al.

PHARMACOLOGICAL RESEARCH (2020)

添加到收藏夹

Article Chemistry, Medicinal

Discovery of Novel Substituted N-(4-Amino-2-chlorophenyl)-5-chloro-2-hydroxybenzamide Analogues as Potent Human Adenovirus Inhibitors

Jimin Xu et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Contributions of Hepatic and Intestinal Metabolism to the Disposition of Niclosamide, a Repurposed Drug with Poor Bioavailability

Xiaoyu Fan et al.

DRUG METABOLISM AND DISPOSITION (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

PrankWeb: a web server for ligand binding site prediction and visualization

Lukas Jendele et al.

NUCLEIC ACIDS RESEARCH (2019)

添加到收藏夹

Article Chemistry, Organic

Synthesis of Oxaphosphinane-Based Pseudodisaccharides

Rachida Babouri et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2017)

添加到收藏夹

Review Cell Biology

Niclosamide: Beyond an antihelminthic drug

Wei Chen et al.

CELLULAR SIGNALLING (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Small molecules targeting severe acute respiratory syndrome human coronavirus

CY Wu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.