期刊
EUROPEAN JOURNAL OF CELL BIOLOGY
卷 101, 期 2, 页码 -出版社
ELSEVIER GMBH
DOI: 10.1016/j.ejcb.2022.151222
关键词
Receptor-mediated endocytosis; Cytoskeleton; Endocytic cytoskeleton; Actin regulation; Membrane bending; FCHSD2
类别
资金
- Academy of Finland
- Sigrid Juselius Foundation
- Finnish Diabetes Research Foundation
- Magnus Ehrnrooth Foundation
- Instruct-ERIC (R&D research award)
In this review, the latest research progress on the endocytic cytoskeleton is summarized, and the physiological significance and unresolved questions of the endocytic cytoskeleton are discussed.
Clathrin-mediated endocytosis (CME) is the major route through which cells internalise various substances and recycle membrane components. Via the coordinated action of many proteins, the membrane bends and in-vaginates to form a vesicle that buds off-along with its contents-into the cell. The contribution of the actin cytoskeleton to this highly dynamic process in mammalian cells is not well understood. Unlike in yeast, where there is a strict requirement for actin in CME, the significance of the actin cytoskeleton to mammalian CME is variable. However, a growing number of studies have established the actin cytoskeleton as a core component of mammalian CME, and our understanding of its contribution has been increasing at a rapid pace. In this review, we summarise the state-of-the-art regarding our understanding of the endocytic cytoskeleton, its physiological significance, and the questions that remain to be answered.
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