4.7 Article

Cetuximab and vemurafenib plus FOLFIRI (5-fluorouracil/leucovorin/irinotecan) for BRAF V600E-mutated advanced colorectal cancer (IMPROVEMENT): An open-label, single-arm, phase II trial

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Randomized Trial of Irinotecan and Cetuximab With or Without Vemurafenib in BRAF-Mutant Metastatic Colorectal Cancer (SWOG S1406)

Scott Kopetz et al.

Summary: Combination therapy of vemurafenib and irinotecan in patients with BRAF(V600E)-mutated colorectal cancer has shown improved progression-free survival, response rate, and disease control rate, as well as reduced BRAF(V600E) variant allele frequency in circulating tumor DNA.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Article Oncology

Encorafenib Plus Cetuximab as a New Standard of Care for Previously Treated BRAF V600E-Mutant Metastatic Colorectal Cancer: Updated Survival Results and Subgroup Analyses from the BEACON Study

Josep Tabernero et al.

Summary: The study evaluated different treatment regimens for patients with BRAF V600E-mutant metastatic colorectal cancer, showing that encorafenib plus cetuximab improved overall survival, objective response rate, and progression-free survival compared to standard chemotherapy.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Review Oncology

Management of BRAF-mutant metastatic colorectal cancer: a review of treatment options and evidence-based guidelines

A. Grothey et al.

Summary: Colorectal cancer remains a leading cause of cancer-related deaths globally, with the mutation in the BRAF gene, particularly the V600E substitution, affecting 10% of metastatic CRC patients and indicating a poor prognosis. Recent advancements in combination therapies targeting the MAPK pathway have shown promising results in treating BRAF V600E-mutated mCRC patients, offering new hope in the management of this subtype of cancer.

ANNALS OF ONCOLOGY (2021)

Article Medicine, General & Internal

Encorafenib, Binimetinib, and Cetuximab in BRAF V600E-Mutated Colorectal Cancer

S. Kopetz et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Medicine, General & Internal

Vemurafenib in Multiple Nonmelanoma Cancers with BRAF V600 Mutations

David M. Hyman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Multidisciplinary Sciences

Comprehensive genomic characterization of squamous cell lung cancers

Peter S. Hammerman et al.

NATURE (2012)

Letter Medicine, General & Internal

BRAF Mutation in Metastatic Colorectal Cancer.

Jolien Tol et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Article Oncology

Wild-Type BRAF Is Required for Response to Panitumumab or Cetuximab in Metastatic Colorectal Cancer

Federica Di Nicolantonio et al.

JOURNAL OF CLINICAL ONCOLOGY (2008)

Article Multidisciplinary Sciences

Mutations of the BRAF gene in human cancer

H Davies et al.

NATURE (2002)