4.7 Article

Middle age serum sodium levels in the upper part of normal range and risk of heart failure

期刊

EUROPEAN HEART JOURNAL
卷 43, 期 35, 页码 3335-3348

出版社

OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/ehac138

关键词

Heart failure; Left ventricular hypertrophy; Risk factors; Prevention; Hydration; Sodium

资金

  1. National Heart, Lung, and Blood Institute (NHLBI): the National Institutes of Health [ZIA-HL006077-10]
  2. NHLBI
  3. National Institutes of Health (NIH)
  4. Department of Health and Human Services [HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700005I, HHSN268201700004I]

向作者/读者索取更多资源

This study found that serum sodium levels above 142 mmol during middle age are associated with an increased risk of left ventricular hypertrophy (LVH) and heart failure (HF). Maintaining good hydration throughout life may help slow down the decline in cardiac function and reduce the prevalence of HF.
Aims With increasing prevalence of heart failure (HF) owing to the ageing population, identification of modifiable risk factors is important. In a mouse model, chronic hypohydration induced by lifelong water restriction promotes cardiac fibrosis. Hypohydration elevates serum sodium. Here, we evaluate the association of serum sodium at middle age as a measure of hydration habits with risk to develop HF. Methods and results We analysed data from Atherosclerosis Risk in Communities study with middle age enrolment (45-66 years) and 25 years of follow-up. Participants without water balance dysregulation were selected: serum sodium within normal range (135-146 mmol/L), not diabetic, not obese and free of HF at baseline (N = 11 814). In time-to-event analysis, HF risk was increased by 39% if middle age serum sodium exceeded 143 mmol/L corresponding to 1% body weight water deficit [hazard ratio 1.39, 95% confidence interval (CI) 1.14-1.70]. In a retrospective case-control analysis performed on 70-to 90-year-old attendees of Visit 5 (N = 4961), serum sodium of 142.5-143 mmol/L was associated with 62% increase in odds of left ventricular hypertrophy (LVH) diagnosis [odds ratio (OR) 1.62, 95% CI 1.03-2.55]. Serum sodium above 143 mmol/L was associated with 107% increase in odds of LVH (OR 2.07, 95% CI 1.30-3.28) and 54% increase in odds of HF (OR 1.54, 95% CI 1.06-2.23). As a result, prevalence of HF and LVH was increased among 70- to 90-year-old participants with higher middle age serum sodium. Conclusion Middle age serum sodium above 142 mmol is a risk factor for LVH and HF. Maintaining good hydration throughout life may slow down decline in cardiac function and decrease prevalence of HF.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据