期刊
EPILEPSIA
卷 63, 期 6, 页码 1398-1442出版社
WILEY
DOI: 10.1111/epi.17241
关键词
benign occipital epilepsy; childhood epilepsy with centrotemporal spikes; continuous spike-and-wave in sleep; eyelid myoclonia; febrile infection-related epilepsy syndrome; hemiconvulsion-hemiplegia-epilepsy syndrome; Landau-Kleffner syndrome; Lennox-Gastaut syndrome; myoclonic absences; myoclonic atonic; Panayiotopoulos syndrome
资金
- National Institutes of Health [U54 NS100064, NS43209]
- US Department of Defense [W81XWH-18-1-0612]
- Segal Family Foundation
- Heffer Family Foundation
- Laurie Marsh/Dan Levitz family
- Abbe Goldstein/Joshua Lurie family
- National Institute of Health Research (NIHR) Biomedical Research Centre at Great Ormond Street Hospital
- Cambridge Biomedical Research Centre
- NIHR
- Evelyn Trust
The 2017 International League Against Epilepsy classification defines a three-tier system for epilepsy syndromes, with childhood onset epilepsy syndromes falling into three categories: self-limited focal epilepsies, generalized epilepsies, and developmental and/or epileptic encephalopathies. Identification of specific syndromes helps guide management and prognosis. This paper describes these childhood onset epilepsy syndromes, highlighting their seizure types, EEG features, phenotypic variations, and key investigation findings.
The 2017 International League Against Epilepsy classification has defined a three-tier system with epilepsy syndrome identification at the third level. Although a syndrome cannot be determined in all children with epilepsy, identification of a specific syndrome provides guidance on management and prognosis. In this paper, we describe the childhood onset epilepsy syndromes, most of which have both mandatory seizure type(s) and interictal electroencephalographic (EEG) features. Based on the 2017 Classification of Seizures and Epilepsies, some syndrome names have been updated using terms directly describing the seizure semiology. Epilepsy syndromes beginning in childhood have been divided into three categories: (1) self-limited focal epilepsies, comprising four syndromes: self-limited epilepsy with centrotemporal spikes, self-limited epilepsy with autonomic seizures, childhood occipital visual epilepsy, and photosensitive occipital lobe epilepsy; (2) generalized epilepsies, comprising three syndromes: childhood absence epilepsy, epilepsy with myoclonic absence, and epilepsy with eyelid myoclonia; and (3) developmental and/or epileptic encephalopathies, comprising five syndromes: epilepsy with myoclonic-atonic seizures, Lennox-Gastaut syndrome, developmental and/or epileptic encephalopathy with spike-and-wave activation in sleep, hemiconvulsion-hemiplegia-epilepsy syndrome, and febrile infection-related epilepsy syndrome. We define each, highlighting the mandatory seizure(s), EEG features, phenotypic variations, and findings from key investigations.
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