期刊
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
卷 92, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.etap.2022.103837
关键词
Arsenic; Unithiol; GSH; Molecular structure; Kinetics; Toxicology
The reaction between DMPS and four phenylarsonic(V) acids was studied in aqueous solution. DMPS reduced the pentavalent arsenic compounds to their trivalent forms and formed covalent As-S bonds. The position and type of polar substituents on the aromatic ring of phenylarsonic acids influenced the reaction rates and the molar ratio of the products. DMPS could replace GSH in the conjugate formed with phenylarsonic(V) acid.
The reaction between 2,3-dimercaptopropane-1-sulfonate (DMPS, unithiol) and four phenylarsonic(V) acids, i.e. phenylarsonic acid (PAA), 4-hydroxy-3-nitrophenylarsonic acid (HNPAA), 2-aminophenylarsonic acid (o-APAA) and 4-aminophenylarsonic acid (p-APAA), is investigated in aqueous solution. The pentavalent arsenic compounds are reduced by DMPS to their trivalent analogs and instantly chelated by the vicinal dithiol, forming covalent As-S bonds within a five-membered chelate ring. The different types and positions of polar substituents at the aromatic ring of the arsonic acids influence the reaction rates in the same way as observed for reaction with glutathione (GSH), as well as the syn/anti molar ratio of the diastereomeric products, which was analyzed using time- and temperature-dependent nuclear magnetic resonance (NMR) spectroscopy. Addition of DMPS to the conjugate formed by a phenylarsonic(V) acid and the biologically relevant tripeptide GSH showed the immediate replacement of GSH by chelating DMPS, underlining the importance of dithiols as detoxifying agent.
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