期刊
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
卷 29, 期 43, 页码 64807-64821出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s11356-022-20353-4
关键词
Trace elements; Early childhood exposure; Cognitive abilities; Gender difference
资金
- National Science Foundation of China [81973062]
- National Key R&D Program of China [2017YFC1600500]
- Science and Technology Commission of Shanghai Municipality [09DZ2200900]
This study explored the influence of trace element levels on the intellectual development of school-aged children. The results showed a negative correlation between lead (Pb) and copper (Cu) levels in cord blood and children's cognitive abilities. Prenatal low-level exposure to arsenic (As) was found to adversely affect girls' intelligence quotient. Additionally, differences in selenium (Se) levels in blood were observed between boys and girls, with high Se levels associated with different effects on cognitive abilities based on gender.
Trace elements persist in the environment, and their early exposure may adversely affect children's intellectual development. To clarify the influence of blood trace element levels in newborns and school-aged children, we used Wechsler Intelligence Scale for children (WISC-CR) to explore intellectual development level of 148 school-aged children based on a population cohort study. Lead (Pb), selenium (Se), arsenic (As), copper (Cu), manganese (Mn) and chromium (Cr) in cord blood and Pb, As, Cu in venous blood were determined by inductively coupled plasma mass spectrometry (ICP-MS) and atomic absorption spectrometer (AAS). Our analysis of the correlation between children's mental development and trace element content found children's cognitive abilities negatively correlate with Pb (PIQ: beta=-0.109, P=0.03737) and Cu (PIQ: beta=-0.031, P=0.04431; FISQ: beta=-0.031, P=0.02137) levels in cord blood. Prenatal low-level As exposure may negatively affect girls' performance intelligence quotient (PIQ) and verbal intelligence quotient (VIQ). There were differences in Se levels in cord blood and venous blood between boys and girls (P=0.010; P=0.073). High Se levels were associated with a lower VIQ in boys and a higher VIQ in girls. Prenatal exposure to Pb, As and Cu may weaken children's cognitive abilities at school age. Se exposure may have opposite effects on cognitive abilities affected by dose and gender.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据