期刊
ENVIRONMENT INTERNATIONAL
卷 161, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.envint.2022.107118
关键词
Handling Editor; Adrian Covaci; Air pollution; Cognition; Cohort; Particulate matter; Nitrogen dioxide; Black carbon
资金
- Agence nationale de securite sanitaire de l'alimentation, de l'environnement et du travail (The French National Research Program for Environmental and Occu-pational Health of ANSES) [2019/1/116]
- Fondation pour la Recherche Medicale
- Caisse Nationale Maladie des Travailleurs Salaries
- Direction Generale de la Sante
- Institut de la Longevite
- Agence Nationale de la Recherche ANR [0601-01, LVIE-003-01]
- Agence Francaise de Securite Sanitaire des Produits de Sante
- Regional Governments of Aquitaine, Bourgogne, and Languedoc-Roussillon
- Ministry of Research-INSERM Programme Cohorts and collection of biological material
- Fondation Plan Alzheimer
- Caisse Nationale de Solidarite pour l'Autonomie (CNSA)
- Novartis
- Fondation de France [00089836]
- MGEN
This study found a link between higher exposure to PM2.5 and accelerated decline in global cognition in a large population-based cohort of French elderly individuals. No significant associations were detected for other pollutants or specific cognitive domains.
Background: Growing epidemiological evidence suggests an adverse relationship between exposure to air pollutants and cognitive decline. However, there is still some heterogeneity in the findings, with inconsistent results depending on the pollutant and the cognitive domain considered. We wanted to determine whether air pollution was associated with global and domain-specific cognitive decline. Methods: This analysis used data from the French Three-City prospective cohort (participants aged 65 and older at recruitment and followed for up to 12 years). A battery of cognitive tests was administered at baseline and every 2 years, to assess global cognition (Mini Mental State Examination, MMSE), visual memory (Benton Visual Retention Test), semantic fluency (Isaacs Set Test) and executive functions (Trail Making Tests A and B). Exposure to fine particulate matter (PM2.5), nitrogen dioxide (NO2) and black carbon (BC) at the participants' residential address during the 5 years before the baseline visit was estimated with land use regression models. Linear mixed models and latent process mixed models were used to assess the association of each pollutant with global and domain-specific cognitive decline. Results: The participants' (n = 6380) median age was 73.4 years (IQR: 8.0), and 61.5% were women. At baseline, the median MMSE score was 28 (IQR: 3). Global cognition decline, assessed with the MMSE, was slightly accelerated among participants with higher PM2.5 exposure: one IQR increment in PM2.5 (1.5 mu g/m3) was associated with accelerated decline (beta: -0.0060 [-0.0112; -0.0007] standard unit per year). Other associations were inconsistent in direction, and of small magnitude. Conclusion: In this large population-based cohort, higher PM2.5 exposure was associated with accelerated global cognition decline. We did not detect any significant association for the specific cognitive domains or the other pollutants. Evidence concerning PM2.5 effects on cognition is growing, but more research is needed on other ambient air pollutants.
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