期刊
EMBO REPORTS
卷 23, 期 6, 页码 -出版社
WILEY
DOI: 10.15252/embr.202154217
关键词
DNA damage; DNA damage repair; inflammation; neurodegeneration; neuron
Neurons are highly susceptible to DNA damage, and deficient DNA damage repair is the underlying cause of neurological disorders. DNA damage may play a central role in neuroinflammation associated with neurodegenerative diseases.
Neurons are highly susceptible to DNA damage accumulation due to their large energy requirements, elevated transcriptional activity, and long lifespan. While newer research has shown that DNA breaks and mutations may facilitate neuron diversity during development and neuronal function throughout life, a wealth of evidence indicates deficient DNA damage repair underlies many neurological disorders, especially age-associated neurodegenerative diseases. Recently, efforts to clarify the molecular link between DNA damage and neurodegeneration have improved our understanding of how the genomic location of DNA damage and defunct repair proteins impact neuron health. Additionally, work establishing a role for senescence in the aging and diseased brain reveals DNA damage may play a central role in neuroinflammation associated with neurodegenerative disease.
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