期刊
DYES AND PIGMENTS
卷 200, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2022.110124
关键词
Semiconducting polymer; NIR-II; Afterglow luminescence; Multimodal imaging
资金
- National Natural Science Foundationof China [61905122, 22174070, 21975131, 22175098]
- Postdoctoral Science Foundation of Jiangsu Province [2021K114B]
- Natural Sci-ence Foundation of the Jiangsu Higher Education Institutions [21KJB430031]
- Synergetic Innovation Center for Organic Electronics and Information Displays
- [21975131,22175098]
Polymer-blend dots (PBdots) with strong fluorescence and afterglow luminescence in both NIR-I and NIR-II windows were successfully fabricated. PBdots provide high resolution and large signal-to-background ratio for imaging of blood vessel, lymph node, and tumor.
Fluorescence imaging at longer wavelength and autofluorescence-free imaging were two main strategies to improve the optical imaging performance of traditional near-infrared (NIR) fluorescence imaging, and the design of corresponding imaging agents were heavily explored recently. Herein, polymer-blend dots (PBdots) with strong fluorescence and afterglow luminescence in both NIR-I (700-900 nm) and NIR-II (900-1700 nm) windows were successfully fabricated by encapsulating two functional semiconducting polymers into one nanoparticle. With efficient intra-particle interactions, the PBdots exhibited an afterglow lifetime of 181 s after 730 nm NIR laser activation, which can be activated in vivo. The obtained PBdots with similar emission intensities in NIR-I and NIR-II regions enable fair comparison between different optical imaging modalities, which provides a clear guidance for the choice of suitable imaging modality for different purpose. As the first imaging agents which integrate NIR-II fluorescence imaging and NIR-I afterglow imaging, the PBdots also provide both high resolution and large signal-to-background ratio for blood vessel, lymph node and tumor imaging in living mice.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据