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Emerging innovations in cold plasma therapy against cancer: A paradigm shift

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DRUG DISCOVERY TODAY
卷 27, 期 9, 页码 2425-2439

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ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2022.05.014

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Cold plasma; Cold atmospheric plasma; Cancer; Plasma oncology; Anticancer therapy

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This article introduces the mechanisms and applications of cold plasma therapy in cancer treatment, allowing readers to understand the current status and prospects of plasma oncology.
Cancer is one of the major causes of mortality, accounting for -9.5 million deaths globally in 2018. The spectrum of conventional treatment for cancer includes surgery, chemotherapy and radiotherapy. Recently, cold plasma therapy surfaced as a novel technique in the treatment of cancer. The FDA approval of the first trial for the use of cold atmospheric plasma (CAP) in cancer therapy in 2019 is evidence of this. This review highlights the mechanisms of action of CAP. Additionally, its applications in anticancer therapy have been reviewed. In summary, this article will introduce the readers to the exciting field of plasma oncology and help them understand the current status and prospects of plasma oncology.

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