期刊
DRUG DISCOVERY TODAY
卷 27, 期 6, 页码 1698-1705出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2022.02.014
关键词
External stimuli-responsive drug delivery; Internal stimuli-responsive drug delivery; Targeted drug delivery; Antibiotic release; Nanoparticles
This review summarizes recent developments in stimuli-based targeted drug delivery systems for the site-specific release of antibiotics. By utilizing various stimuli, controlled and timely release of antibiotics at the site of infection can be achieved.
Site-specific delivery of antibiotics has always been a high-priority area in pharmaceutical research. Conventionally used antibiotics suffer several limitations, such as low accumulation and penetration in diseased cells/tissues, limited bioavailability of drugs, drug resistance, and off-target toxicity. To overcome these limitations, several strategies have been exploited for delivering antibiotics to the site of infection, such as the use of stimuli-responsive antibiotic delivery systems, which can release antibiotics in a controlled and timely fashion. These stimuli can either be exogenous (light, magnetism, ultrasound, and electrical) or endogenous (pH, redox reactions, and enzymatic). In this review, we present a summary of recent developments in the field of stimuli-based targeted drug delivery systems for the site-specific release of antibiotics.
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