4.5 Editorial Material

Lord of the fruit flies: an interview with Hugo Bellen

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Editorial Material Developmental Biology

Model organism databases are in jeopardy

Hugo J. Bellen et al.

DEVELOPMENT (2021)

Article Multidisciplinary Sciences

Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease-associated genes

Matthew J. Moulton et al.

Summary: The study reveals that the increasing genetic risk factors for Alzheimer's disease have unclear contributions to the disease mechanism, but the neuron-to-glia lipid transfer pathway induced by ROS plays a key role in protecting against neurotoxicity.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Genetics & Heredity

Model organisms contribute to diagnosis and discovery in the undiagnosed diseases network: current state and a future vision

Dustin Baldridge et al.

Summary: With the decrease in sequencing costs, there has been a rapid increase in genetic and genomic data, raising the challenge of determining which variants cause phenotypes and diseases. Platforms using model organisms have enabled the discovery of new gene-disease relationships and the identification of variant pathogenicity, leading to suggestions for new therapies.

ORPHANET JOURNAL OF RARE DISEASES (2021)

Article Biochemistry & Molecular Biology

A Drosophila Genetic Resource of Mutants to Study Mechanisms Underlying Human Genetic Diseases

Shinya Yamamoto et al.