4.5 Review

Sessile serrated lesions: Clinicopathological characteristics, endoscopic diagnosis, and management

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Cancer Risk in Patients With and Relatives of Serrated Polyposis Syndrome and Sporadic Sessile Serrated Lesions

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Summary: Patients with serrated polyposis syndrome (SPS) and their relatives, especially first-degree relatives, have an increased risk of colorectal cancer (CRC). In addition, an increased risk of prostate cancer was found in patients with sporadic sessile serrated lesion (SSL). Relatives of patients with both sporadic SSL and adenomas may also have an elevated CRC risk.

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Usefulness of the Japan narrow-band imaging expert team classification system for the diagnosis of sessile serrated lesion with dysplasia/carcinoma

Takashi Murakami et al.

Summary: The study aimed to verify the usefulness of the Japan NBI Expert Team (JNET) classification system for diagnosing SSLs with dysplasia/carcinoma using 709 resected lesions. Results showed that tumors were more frequently located in the proximal colon, and submucosal invasive carcinomas were significantly larger. NBI characteristic dark spots were found in the majority of lesions, and the JNET classification demonstrated high sensitivity, specificity, and overall diagnostic accuracy in diagnosing SSLs with dysplasia/carcinoma.

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Cold snare polypectomy for large sessile serrated lesions is safe but follow-up is needed: A single-centre retrospective study

Naohisa Yoshida et al.

Summary: The study aimed to evaluate the feasibility of CSP for SSLs >= 10 mm in size and found it to be safe and promising, but with a slightly higher rate of recurrence, indicating the need for close follow-up. The en bloc resection rate was 60.0% with low rates of adverse events such as hemorrhage and perforation. Risk factors for recurrence were not significant, and all recurrent cases could be resected by repeat CSP.

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The prevalence of sessile serrated lesion in the colorectum and its relationship to synchronous colorectal advanced neoplasia: a systemic review and meta-analysis

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Summary: This study evaluated the prevalence of sessile serrated lesion (SSL) and its relationship to synchronous colorectal advanced neoplasia, finding an increased risk of synchronous advanced neoplasia in the colorectum associated with SSL.

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Summary: A study in Australia compared the effectiveness of p-CSP and traditional EMR in managing large L-SSLs. The study found that p-CSP was technically as effective as EMR but significantly reduced the risk of delayed bleeding and perforation. Therefore, p-CSP should be considered the new standard of care for treating L-SSLs.
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