Autoimmune Hepatitis-Like Syndrome Following COVID-19 Vaccination: A Systematic Review of the Literature

Summary: A 26-year-old woman developed immune thrombocytopenic purpura and transaminitis 2 weeks after receiving the Moderna mRNA-1273 vaccine. Treatment with steroids and immunoglobulin led to improvement in platelet count and liver enzymes. The temporal relationship suggests the vaccine as a potential inciting factor.

BMJ CASE REPORTS (2021)

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Article Immunology

Autoimmune hepatitis after COVID-19 vaccine-more than a coincidence

Isabel Garrido et al.

Summary: The case of acute severe autoimmune hepatitis following COVID-19 vaccination highlights the importance of closely monitoring adverse reactions during the vaccination process to ensure safety. Healthcare providers must remain vigilant during mass COVID-19 vaccination to detect and manage potential complications promptly.

JOURNAL OF AUTOIMMUNITY (2021)

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Letter Gastroenterology & Hepatology

Autoimmune hepatitis developing after coronavirus disease 2019 (COVID-19) vaccine: Causality or casualty?

Fernando Bril et al.

JOURNAL OF HEPATOLOGY (2021)

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Article Medicine, General & Internal

Prevalence of COVID-19 Vaccine Side Effects among Healthcare Workers in the Czech Republic

Abanoub Riad et al.

Summary: The study conducted a survey on the side effects of the Pfizer-BioNTech COVID-19 vaccine among healthcare workers in the Czech Republic, revealing common side effects such as injection site pain, fatigue, and headache. Younger age groups and individuals who received two doses of the vaccine were more likely to experience side effects, with the overall prevalence of side effects higher than reported by the manufacturer.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Psychology, Biological

A global database of COVID-19 vaccinations

Edouard Mathieu et al.

Summary: An effective rollout of COVID-19 vaccines is crucial in ending the pandemic, and Our World in Data's vaccination dataset tracks the progress and scale of vaccine distribution globally, aiding policymakers and researchers in understanding the global vaccination efforts.

NATURE HUMAN BEHAVIOUR (2021)

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Article Medicine, General & Internal

Surveillance for Adverse Events After COVID-19 mRNA Vaccination

Nicola P. Klein et al.

Summary: This study conducted interim analysis of safety surveillance data of mRNA COVID-19 vaccines and found that the incidence of selected serious outcomes within 1-21 days post-vaccination was not significantly higher compared with 22-42 days post-vaccination. Surveillance is ongoing despite wide confidence intervals for many outcomes.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Immunology

Acute autoimmune-like hepatitis with atypical anti-mitochondrial antibody after mRNA COVID-19 vaccination: A novel clinical entity?

Michele Ghielmetti et al.

Summary: This case report describes a 63-year-old man who developed acute severe autoimmune-like hepatitis seven days after receiving the mRNA1273 SARS-CoV-2 vaccine, despite having no history of autoimmunity or natural infection with the virus. The patient displayed unique autoimmune liver serology patterns, including an atypical anti-mitochondrial antibody (AMA) and a distinct type of anti-nuclear antibody (ANA). Treatment with prednisone was effective for this emerging condition.

JOURNAL OF AUTOIMMUNITY (2021)

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Article Immunology

Autoimmune hepatitis triggered by SARS-CoV-2 vaccination

Elise Vuille-Lessard et al.

Summary: Autoimmune diseases have been reported to develop after SARS-CoV-2 infection, as well as following vaccination against the virus. The potential mechanisms involve molecular mimicry and bystander activation. Further investigation is needed to understand the link between SARS-CoV2 vaccination and autoimmune diseases.

JOURNAL OF AUTOIMMUNITY (2021)

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Article Immunology

Auto-immune hepatitis following COVID vaccination

Mohamed Rela et al.

Summary: The COVID pandemic has led to unprecedented loss of life and the rapid development of vaccines. While most vaccines have been approved quickly, there are concerns about their potential side effects, including rare cases of autoimmune hepatitis. Close monitoring and pharmacovigilance are essential in guiding treatment and ensuring vaccine safety.

JOURNAL OF AUTOIMMUNITY (2021)

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Letter Gastroenterology & Hepatology

Autoimmune hepatitis developing after the ChAdOx1 nCoV-19 (Oxford-AstraZeneca) vaccine

Daniel Clayton-Chubb et al.

JOURNAL OF HEPATOLOGY (2021)

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Letter Gastroenterology & Hepatology

Another case of autoimmune hepatitis after SARS-CoV-2 vaccination - still casualty?

Maria-Carlota Londono et al.

JOURNAL OF HEPATOLOGY (2021)

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Letter Gastroenterology & Hepatology

Autoimmune hepatitis following COVID-19 vaccination: True causality or mere association?

Chin Kimg Tan et al.

JOURNAL OF HEPATOLOGY (2021)

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Letter Gastroenterology & Hepatology

Autoimmune hepatitis following SARS-CoV-2 vaccine: May not be a casuality

Alba Rocco et al.

JOURNAL OF HEPATOLOGY (2021)

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Letter Gastroenterology & Hepatology

An unusual case of acute cholestatic hepatitis after m-RNABNT162b2 (Comirnaty) SARS-CoV-2 vaccine: Coincidence, autoimmunity or drug- related liver injury

Francesca Lodato et al.

JOURNAL OF HEPATOLOGY (2021)

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Letter Gastroenterology & Hepatology

The mRNA COVID-19 vaccine - A rare trigger of autoimmune hepatitis?

Cathy McShane et al.

JOURNAL OF HEPATOLOGY (2021)

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Article Medicine, General & Internal

Safety of the BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting

Noam Barda et al.

Summary: The study found that after receiving the BNT162b2 vaccine, most adverse events were not associated with an increased risk, although there was a slight increase in the risk of myocarditis. On the other hand, infection with the Covid-19 virus significantly increased the risk of many serious adverse events.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Public, Environmental & Occupational Health

Comparative Effectiveness of Moderna, Pfizer-BioNTech, and Janssen (Johnson & Johnson) Vaccines in Preventing COVID-19 Hospitalizations Among Adults Without Immunocompromising Conditions — United States, March–August 2021

Wesley H. Self et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

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Article Immunology

Acute Immune Thrombocytopenia (ITP) Following COVID-19 Vaccination in a Patient With Previously Stable ITP

Muzamil Jawed et al.

Summary: The COVID-19 vaccine may lead to immune thrombocytopenia (ITP), but the mechanisms behind this association remain unclear and require further research.

OPEN FORUM INFECTIOUS DISEASES (2021)

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Article Gastroenterology & Hepatology