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注意:仅列出部分参考文献,下载原文获取全部文献信息。Glucolipotoxicity, β-Cells, and Diabetes: The Emperor Has No Clothes
Gordon C. Weir
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Nutrient Metabolism, Subcellular Redox State, and Oxidative Stress in Pancreatic Islets and β-Cells
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JOURNAL OF MOLECULAR BIOLOGY (2020)
Beta Cell Dedifferentiation Induced by IRE1α Deletion Prevents Type 1 Diabetes
Hugo Lee et al.
CELL METABOLISM (2020)
Raptor determines β-cell identity and plasticity independent of hyperglycemia in mice
Qinglei Yin et al.
NATURE COMMUNICATIONS (2020)
Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis
Christian M. Cohrs et al.
CELL REPORTS (2020)
Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure
Decio L. Eizirik et al.
NATURE REVIEWS ENDOCRINOLOGY (2020)
Intersection of the ATF6 and XBP1 ER stress pathways in mouse islet cells
Rohit B. Sharma et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2020)
Early beta cell dysfunction vs insulin hypersecretion as the primary event in the pathogenesis of dysglycaemia
Nathalie Esser et al.
DIABETOLOGIA (2020)
Amygdala NPY Circuits Promote the Development of Accelerated Obesity under Chronic Stress Conditions
Chi Kin Ip et al.
CELL METABOLISM (2019)
Atf6α impacts cell number by influencing survival, death and proliferation
Rohit B. Sharma et al.
MOLECULAR METABOLISM (2019)
Targeting innate immune mediators in type 1 and type 2 diabetes
Marc Y. Donath et al.
NATURE REVIEWS IMMUNOLOGY (2019)
Mechanisms of β-cell dedifferentiation in diabetes: recent findings and future research directions
Mohammed Bensellam et al.
JOURNAL OF ENDOCRINOLOGY (2018)
IRE1-XBP1 pathway regulates oxidative proinsulin folding in pancreatic beta cells
Yuichi Tsuchiya et al.
JOURNAL OF CELL BIOLOGY (2018)
Replication confers β cell immaturity
Sapna Puri et al.
NATURE COMMUNICATIONS (2018)
Biosynthesis, structure, and folding of the insulin precursor protein
Ming Liu et al.
DIABETES OBESITY & METABOLISM (2018)
Pancreatic β cell identity requires continual repression of non-β cell programs
Giselle Dominguez Gutierrez et al.
JOURNAL OF CLINICAL INVESTIGATION (2017)
PAX6 maintains β cell identity by repressing genes of alternative islet cell types
Avital Swisa et al.
JOURNAL OF CLINICAL INVESTIGATION (2017)
Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis
Chunguang Chen et al.
MOLECULAR METABOLISM (2017)
Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation
Marta Szabat et al.
CELL METABOLISM (2016)
A Reevaluation of the Role of the Unfolded Protein Response in Islet Dysfunction: Maladaptation or a Failure to Adapt?
Terence P. Herbert et al.
DIABETES (2016)
Transcriptional Regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4 (HNF4) Is Vital to Beta-cell Function
Benjamin D. Moore et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes
Francesca Cinti et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2016)
IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation
Tomozumi Takatani et al.
SCIENTIFIC REPORTS (2016)
Insulin demand regulates β cell number via the unfolded protein response
Rohit B. Sharma et al.
JOURNAL OF CLINICAL INVESTIGATION (2015)
Role of transcription factors in the transdifferentiation of pancreatic islet cells
Talitha van der Meulen et al.
JOURNAL OF MOLECULAR ENDOCRINOLOGY (2015)
The balance between adaptive and apoptotic unfolded protein responses regulates β-cell death under ER stress conditions through XBP1, CHOP and JNK
Jeng Yie Chan et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2015)
The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells
Justin R. Hassler et al.
PLOS BIOLOGY (2015)
MafA is critical for maintenance of the mature beta cell phenotype in mice
Wataru Nishimura et al.
DIABETOLOGIA (2015)
JunB protects β-cells from lipotoxicity via the XBP1-AKT pathway
D. A. Cunha et al.
CELL DEATH AND DIFFERENTIATION (2014)
Pancreatic β Cell Dedifferentiation in Diabetes and Redifferentiation following Insulin Therapy
Zhiyu Wang et al.
CELL METABOLISM (2014)
Pdx1 Maintains β Cell Identity and Function by Repressing an α Cell Program
Tao Gao et al.
CELL METABOLISM (2014)
SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells
Melkam A. Kebede et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
Cell type-specific mRNA purification by translating ribosome affinity purification (TRAP)
Myriam Heiman et al.
NATURE PROTOCOLS (2014)
Reversible changes in pancreatic islet structure and function produced by elevated blood glucose
Melissa F. Brereton et al.
NATURE COMMUNICATIONS (2014)
Aberrant islet unfolded protein response in type 2 diabetes
Feyza Engin et al.
SCIENTIFIC REPORTS (2014)
Failure of the Adaptive Unfolded Protein Response in Islets of Obese Mice Is Linked With Abnormalities in β-Cell Gene Expression and Progression to Diabetes
Jeng Yie Chan et al.
DIABETES (2013)
Conversion of Mature Human β-Cells Into Glucagon-Producing α-Cells
H. Siebe Spijker et al.
DIABETES (2013)
VHL-mediated disruption of Sox9 activity compromises β-cell identity and results in diabetes mellitus
Sapna Puri et al.
GENES & DEVELOPMENT (2013)
Nkx6.1 Is Essential for Maintaining the Functional State of Pancreatic Beta Cells
Brandon L. Taylor et al.
CELL REPORTS (2013)
Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell Identity
Ashleigh E. Schaffer et al.
PLOS GENETICS (2013)
Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure
Chutima Talchai et al.
CELL (2012)
Deciphering c-MYC-regulated genes in two distinct tissues
Samuel C. Robson et al.
BMC GENOMICS (2011)
Pancreatic β Cell Identity Is Maintained by DNA Methylation-Mediated Repression of Arx
Sangeeta Dhawan et al.
DEVELOPMENTAL CELL (2011)
Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming
James B. Papizan et al.
GENES & DEVELOPMENT (2011)
Hepatic Nuclear Factor 1α (HNF1α) Dysfunction Down-regulates X-box-binding Protein 1 (XBP1) and Sensitizes β-Cells to Endoplasmic Reticulum Stress
Clare L. Kirkpatrick et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Dual and opposing roles of the unfolded protein response regulated by IRE1α and XBP1 in proinsulin processing and insulin secretion
Ann-Hwee Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis
F. Allagnat et al.
DIABETOLOGIA (2010)
IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates
Dan Han et al.
CELL (2009)
Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes
Benbo Song et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Embryonic endocrine pancreas and mature β cells acquire α and PP cell phenotypes upon Arx misexpression
Patrick Collombat et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1
Kathryn L. Lipson et al.
CELL METABOLISM (2006)
Islet β cell failure in type 2 diabetes
Marc Prentki et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of β-cell differentiation and secretory function in the db/db mouse model of diabetes
C Kjorholt et al.
DIABETES (2005)
beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
AE Butler et al.
DIABETES (2003)
A role for glutathione peroxidase in protecting pancreatic β cells against oxidative stress in a model of glucose toxicity
Y Tanaka et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Overexpression of c-Myc in β-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes
DR Laybutt et al.
DIABETES (2002)