期刊
DIABETES TECHNOLOGY & THERAPEUTICS
卷 -, 期 -, 页码 -出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/dia.2022.0085
关键词
Diabetes mellitus; Flash glucose monitoring; Diabetic ketoacidosis; Hypoglycemia; Claims analyses; Hospitalization
资金
- AbbottDiabetes Care
The RELIEF study demonstrates that the use of flash glucose monitoring system effectively reduces hospitalization rates for acute diabetes events, especially DKA, in both type 1 and type 2 diabetes patients. Additionally, there is a clear and progressive decrease in the use of blood glucose test strips over the 2-year period.
Background: The RELIEF study has previously shown a fall in the rate of acute diabetes events (ADEs) in people living with type 1 diabetes (PwDT1) or people living with type 2 diabetes (PwDT2) in the 12 months after initiation of flash glucose monitoring (FLASH) in France. The 2-year follow-up has provided new insights on the frequency of ADEs, including severe hypoglycemia and diabetic ketoacidosis (DKA), during use of FLASH.Methods: The RELIEF study included 31,446 PwDT1 and 41,027 PwDT2 with a first delivery of FreeStyle Libre (FSL) between August 1 and December 31, 2017. Hospitalizations for DKA, severe hypoglycemia, diabetes-related coma, and hyperglycemia were recorded for the 12 months before and 24 months after FSL initiation. Persistence of the FSL system use was estimated through a Kaplan-Meier survival curve. Change in usual blood glucose monitoring was estimated through acquisition of blood glucose test strips.Results: In the 2 years after FSL initiation, hospitalizations for ADEs were reduced by 49% and by 48% in PwDT1 or PwDT2, respectively, driven by reductions in DKA. After 2 years, 88% of patients persisted with the system and estimated mean consumption of blood glucose test strips had fallen after 2 years by -82% and by -84% in type 1 diabetes mellitus and type 2 diabetes mellitus, respectively.Conclusion: Use of FSL consistently reduces the rates of hospitalization for ADEs, mainly DKA, 2 years after initiation, confirming this is not a transitory effect. Use of FSL also results in a clear and progressive drop in use of blood glucose test strips over the 2-year period.
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