☆ 4.7 Review

Nonalcoholic fatty liver disease and osteoporosis: A potential association with therapeutic implications

DIABETES OBESITY & METABOLISM (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Editorial Material Pharmacology & Pharmacy

Cilofexor for the Treatment of Nonalcoholic Steatohepatitis

Stergios A. Polyzos et al.

CURRENT VASCULAR PHARMACOLOGY (2022)

添加到收藏夹

Review Endocrinology & Metabolism

Insights into the molecular targets and emerging pharmacotherapeutic interventions for nonalcoholic fatty liver disease

Chander K. Negi et al.

Summary: NAFLD is the most common form of chronic liver disease worldwide, with current treatment options including dietary restrictions and lifestyle modification. It is closely associated with metabolic disorders such as obesity, type 2 diabetes, and dyslipidemia, with various pharmacological approaches being considered in clinical management.

METABOLISM-CLINICAL AND EXPERIMENTAL (2022)

添加到收藏夹

Article Endocrinology & Metabolism

Prevalence and Trends in Low Bone Density, Osteopenia and Osteoporosis in US Adults With Non-Alcoholic Fatty Liver Disease, 2005-2014

Tianyu Zhai et al.

Summary: This study found that US adults with non-alcoholic fatty liver disease (NAFLD) had a trend towards lower bone mineral density (BMD) and a higher prevalence of osteopenia/osteoporosis at the femoral neck from 2005-2014. NAFLD with advanced fibrosis was also associated with a higher risk of spine fractures. Further research is needed to understand the mechanisms and consequences of poor bone health in NAFLD patients and develop optimal management strategies for osteopenia/osteoporosis in this population.

FRONTIERS IN ENDOCRINOLOGY (2022)

添加到收藏夹

Review Endocrinology & Metabolism

Efficacy of lower doses of pioglitazone after stroke or transient ischaemic attack in patients with insulin resistance

J. David Spence et al.

Summary: This study evaluated the effectiveness and risks of lower versus higher doses of pioglitazone in patients with stroke. The results showed that lower doses of pioglitazone had fewer adverse effects while still providing substantial effects in preventing cardiovascular events and new-onset diabetes.

DIABETES OBESITY & METABOLISM (2022)

添加到收藏夹

Article Gastroenterology & Hepatology

From NAFLD to MAFLD: Implications of a Premature Change in Terminology

Zobair M. Younossi et al.

Summary: The article discusses the proposal to rename NAFLD to MAFLD, highlighting the shortcomings of the new term and warning that changing the name without a comprehensive understanding may have negative implications for the field. The recommendation is to establish a true international consensus group to assess the impact and consequences of the terminology change and make recommendations based on available evidence to move the field forward.

HEPATOLOGY (2021)

添加到收藏夹

Review Medicine, Research & Experimental

Epidemiology, Pathogenesis, Diagnosis and Emerging Treatment of Nonalcoholic Fatty Liver Disease

Evangelia Makri et al.

Summary: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, with its prevalence rising due to increasing rates of obesity and type 2 diabetes. The pathogenesis of NAFLD is not fully understood, with factors such as adipokines, gut microbiota, and genetic predisposition playing a role in addition to weight gain and insulin resistance. Liver biopsy is currently the gold standard for diagnosis and staging, but early use of noninvasive biomarkers is essential for identifying patients at different stages of the disease.

ARCHIVES OF MEDICAL RESEARCH (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Osteocalcin and Non-Alcoholic Fatty Liver Disease: Lessons From Two Population-Based Cohorts and Animal Models

Mingfeng Xia et al.

Summary: The study reveals an inverse association between circulating osteocalcin levels and non-alcoholic fatty liver disease (NAFLD), with osteocalcin reducing liver lipogenesis by decreasing SREBP-1c expression.

JOURNAL OF BONE AND MINERAL RESEARCH (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Treatment of nonalcoholic fatty liver disease with an anti-osteoporotic medication: A hypothesis on drug repurposing

Stergios A. Polyzos et al.

Summary: NAFLD is a highly prevalent liver disease without any approved treatment. This study explores the potential association between hepatic RANKL upregulation and the pathogenesis of NAFLD, suggesting denosumab as a potential candidate for NASH in drug-repurposing studies.

MEDICAL HYPOTHESES (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Hepatic fibrosis is associated with an increased rate of decline in bone mineral density in men with nonalcoholic fatty liver disease

Ji Won Yoon et al.

Summary: This study found no significant association between NAFLD and the decline rate of total hip BMD, but among men with NAFLD, those at high and intermediate risk of advanced fibrosis showed a significantly increased decline rate in total hip BMD.

HEPATOLOGY INTERNATIONAL (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Osteocalcin Alleviates Nonalcoholic Fatty Liver Disease in Mice through GPRC6A

Mingliang Zhang et al.

Summary: The study found that uncarboxylated osteocalcin alleviates NAFLD in mice through the GPRC6A signaling pathway by inhibiting lipid synthesis and promoting lipolysis. Liver GPRC6A may be a potential target for treating NAFLD.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Association Between Liver Fat and Bone Density is Confounded by General and Visceral Adiposity in a Community-Based Cohort

Belinda T. Li et al.

Summary: In a cohort study, the association between NAFLD and BMD and vertebral strength was influenced by BMI and VAT, while NAFLD was weakly associated with a reduced vertebral CSA in adjusted models.

OBESITY (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Pegbelfermin, a PEGylated FGF21 analogue, has pharmacology without bone toxicity after 1-year dosing in skeletally-mature monkeys

Kary E. Thompson et al.

Summary: The study demonstrates that after one year of administration at clinically relevant doses, PGBF does not adversely affect bone metabolism, density, or strength in adult monkeys.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2021)

添加到收藏夹

Review Immunology

Interleukin-17A Interweaves the Skeletal and Immune Systems

Mengjia Tang et al.

Summary: The interaction between the immune and skeletal systems is crucial for maintaining skeletal homeostasis, with IL-17A playing a key role; IL-17A has dual effects on osteoclasts and osteoblasts, and is involved in immune-mediated bone diseases; Understanding the pathophysiological roles of IL-17A may offer potential strategies for treating immune-mediated bone diseases.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Review Medicine, Research & Experimental

Perspectives on Precision Medicine Approaches to NAFLD Diagnosis and Management

Amedeo Lonardo et al.

Summary: Precision medicine aims to identify the most effective treatment approaches for patients based on their genetic background, clinical features, and environmental factors. The heterogeneity of NAFLD/MAFLD is influenced by factors such as sex, genetics, intestinal microbiota, endocrine and metabolic status, and physical activity, which can help in forming individualized treatment plans. Consideration of NAFLD heterogeneity plays a significant role in the development of targeted therapies for specific subgroups of NAFLD.

ADVANCES IN THERAPY (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Evaluation of the risk of fracture in type 2 diabetes mellitus patients with incretins: an updated meta-analysis

Qing-Xin Kong et al.

Summary: This meta-analysis suggests that the current use of incretins is not associated with increased risk of fracture in type 2 diabetes patients, and in some cases, such as when taking sitagliptin 100 mg or liraglutide 1.8 mg per day, it may even reduce fracture risk.

ENDOKRYNOLOGIA POLSKA (2021)

添加到收藏夹

Review Endocrinology & Metabolism

NLRP3 Inflammasome: A New Target for Prevention and Control of Osteoporosis?

Na Jiang et al.

Summary: The NLRP3 inflammasome plays a crucial role in the pathogenesis of osteoporosis by affecting the differentiation of osteoblasts and osteoclasts, resulting in accelerated bone resorption and inhibited bone formation. Abnormal activation of the inflammasome can lead to inflammation, pyroptosis, and dysfunction of osteoblasts, highlighting it as a potential therapeutic target for managing osteoporosis.

FRONTIERS IN ENDOCRINOLOGY (2021)

添加到收藏夹

Article Endocrinology & Metabolism

NAFLD and Liver Fibrosis Are Not Associated With Reduced Femoral Bone Mineral Density in the General US Population

Stefano Ciardullo et al.

Summary: The study investigated the association between liver steatosis and fibrosis with reduced bone mineral density in the US population aged 50 and above. Results showed a high prevalence of steatosis and significant fibrosis in the study population, but after adjustment, liver steatosis and fibrosis were not found to be associated with reduced BMD.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

添加到收藏夹

Article Geriatrics & Gerontology

Postmenopausal osteoporosis coexisting with other metabolic diseases: Treatment considerations

Stergios A. Polyzos et al.

Summary: Osteoporosis often coexists with metabolic diseases in postmenopausal women, suggesting shared pathogenetic mechanisms. Anti-osteoporotic medications may affect the pathogenesis of some metabolic diseases, while medications for metabolic diseases may adversely affect bone metabolism. Understanding the links between osteoporosis and metabolic diseases may have clinical implications.

MATURITAS (2021)

添加到收藏夹

Review Gastroenterology & Hepatology

Non-alcoholic fatty liver disease: a multisystem disease requiring a multidisciplinary and holistic approach

Giovanni Targher et al.

Summary: NAFLD is not only a global public health issue but also proven to be a systemic disease, closely related to various extrahepatic complications. Addressing NAFLD requires establishing a multidisciplinary working group and framework to achieve comprehensive, person-centered care and management.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2021)

添加到收藏夹

Review Gastroenterology & Hepatology

Review article: non-alcoholic fatty liver disease and cardiovascular diseases: associations and treatment considerations

Stergios A. Polyzos et al.

Summary: The association between non-alcoholic fatty liver disease (NAFLD) and cardiovascular diseases (CVD) has been established, with weight management through lifestyle modifications remaining crucial and pharmacological treatment potentially important. Various medications have shown promising results in managing NAFLD and CVD, but careful consideration is needed for their use due to potential adverse effects.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Sodium-glucose co-transporter 2 inhibitors in nonalcoholic fatty liver disease

Evangelia S. Makri et al.

Summary: NAFLD is a common liver disease with potentially severe consequences, and pharmacological therapy is still lacking. SGLT-2 inhibitors show promising potential for treating NAFLD, especially in improving liver function.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

添加到收藏夹

Review Gastroenterology & Hepatology

Circulating tumor necrosis factor-α levels in non-alcoholic fatty liver disease: A systematic review and a meta-analysis

Victoria Potoupni et al.

Summary: The study synthesized data on circulating TNF-alpha levels in patients with NAFLD and controls. It found that TNF-alpha levels were higher in NAFLD patients than controls, and were also associated with the severity of NAFLD. Additionally, male ratio was positively associated with TNF-alpha levels in the comparison between NASH and NAFL patients.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Effects of GLP-1 Receptor Agonists on Bone Mineral Density in Patients with Type 2 Diabetes Mellitus: A 52-Week Clinical Study

Ting-ting Cai et al.

Summary: This study found that GLP-1 receptor agonists may increase BMD at multiple sites in patients with T2DM after treatment, potentially without exacerbating the consequences of bone fragility.

BIOMED RESEARCH INTERNATIONAL (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

The Impact of Glucagon-Like Peptide 1 Receptor Agonists on Bone Metabolism and Its Possible Mechanisms in Osteoporosis Treatment

Baocheng Xie et al.

Summary: Diabetes mellitus and osteoporosis are closely related, and GLP-1RAs may help in controlling blood sugar levels and promoting bone formation, but more research is needed to clarify their specific effects and mechanisms.

FRONTIERS IN PHARMACOLOGY (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Non-Alcoholic Fatty Liver Disease Treatment in Patients with Type 2 Diabetes Mellitus; New Kids on the Block

Vasilios G. Athyros et al.

CURRENT VASCULAR PHARMACOLOGY (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Uncarboxylated osteocalcin ameliorates hepatic glucose and lipid metabolism in KKAy mice via activating insulin signaling pathway

Xiao-lin Zhang et al.

ACTA PHARMACOLOGICA SINICA (2020)

添加到收藏夹

Article Endocrinology & Metabolism

Increased risk of low bone mineral density in patients with non-alcoholic fatty liver disease: a cohort study

Zhe Shen et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2020)

添加到收藏夹

Review Endocrinology & Metabolism

Sodium-Glucose Co-Transporter 2 Inhibitors and Fracture Risk

Anastasia Erythropoulou-Kaltsidou et al.

DIABETES THERAPY (2020)

添加到收藏夹

Article Endocrinology & Metabolism

Pharmacological Management of Osteoporosis in Postmenopausal Women: An Endocrine Society Guideline Update

Dolores Shoback et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2020)

添加到收藏夹

Article Endocrinology & Metabolism

Obeticholic acid for the treatment of nonalcoholic steatohepatitis: Expectations and concerns

Stergios A. Polyzos et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2020)

添加到收藏夹

Article Endocrinology & Metabolism

Current and emerging pharmacological options for the treatment of nonalcoholic steatohepatitis

Stergios A. Polyzos et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Osteopontin acts as a negative regulator of autophagy accelerating lipid accumulation during the development of nonalcoholic fatty liver disease

Min Tang et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2020)

添加到收藏夹

Article Endocrinology & Metabolism

Effects of Novel Dual GIP and GLP-1 Receptor Agonist Tirzepatide on Biomarkers of Nonalcoholic Steatohepatitis in Patients With Type 2 Diabetes

Mark L. Hartman et al.

DIABETES CARE (2020)

添加到收藏夹

Article Cell Biology

Neutralizing antibody against osteopontin attenuates non-alcoholic steatohepatitis in mice

Machiko Honda et al.

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2020)

添加到收藏夹

Article Gastroenterology & Hepatology

A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement

Mohammed Eslam et al.

JOURNAL OF HEPATOLOGY (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

RANKL Is Involved in Runx2-Triggered Hepatic Infiltration of Macrophages in Mice with NAFLD Induced by a High-Fat Diet

Li Zhong et al.

BIOMED RESEARCH INTERNATIONAL (2020)

添加到收藏夹

Review Endocrinology & Metabolism

NAFLD and NASH in Postmenopausal Women: Implications for Diagnosis and Treatment

Johanna K. DiStefano

ENDOCRINOLOGY (2020)

添加到收藏夹

Article Endocrinology & Metabolism

Association between non-alcoholic fatty liver disease-associated hepatic fibrosis and bone mineral density in postmenopausal women with type 2 diabetes or impaired glucose regulation

Xiaopeng Zhu et al.

BMJ OPEN DIABETES RESEARCH & CARE (2020)

添加到收藏夹

Article Endocrinology & Metabolism

Making progress in nonalcoholic fatty liver disease (NAFLD) as we are transitioning from the era of NAFLD to dys-metabolism associated fatty liver disease (DAFLD)

Stergios A. Polyzos et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2020)

添加到收藏夹

Editorial Material Endocrinology & Metabolism

Commentary: Nonalcoholic or metabolic dysfunction-associated fatty liver disease? The epidemic of the 21st century in search of the most appropriate name

Stergios A. Polyzos et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2020)

添加到收藏夹

Review Cell Biology

Sexual Dimorphism in Osteoclasts

Joseph Lorenzo

CELLS (2020)

添加到收藏夹

Article Endocrinology & Metabolism

Comparative effectiveness of glucagon-like peptide-1 receptor agonists versus dipeptidyl peptidase-4 inhibitors on noninvasive indices of hepatic steatosis and fibrosis in patients with type 2 diabetes mellitus

Evangelia Makri et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Vitamin D and non-alcoholic fatty liver disease: a meta-analysis of randomized controlled trials

Xiao-fei Guo et al.

FOOD & FUNCTION (2020)

添加到收藏夹

Article Nutrition & Dietetics

The Efficacy of Vitamin D Supplementation against Nonalcoholic Fatty Liver Disease: A Meta-Analysis

Fariborz Mansour-Ghanaei et al.

JOURNAL OF DIETARY SUPPLEMENTS (2020)

添加到收藏夹

Article Endocrinology & Metabolism

Nonalcoholic fatty liver disease in males with low testosterone concentrations

Stergios A. Polyzos et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2020)

添加到收藏夹

Article Endocrinology & Metabolism

Fibroblast Growth Factor 21 Is Associated With Bone Mineral Density, but not With Bone Turnover Markers and Fractures in Chinese Postmenopausal Women

WeiWei Hu et al.

JOURNAL OF CLINICAL DENSITOMETRY (2019)

添加到收藏夹

Article Endocrinology & Metabolism

Risk of bone fracture associated with sodium-glucose cotransporter-2 inhibitor treatment: A meta-analysis of randomized controlled trials

L. Cheng et al.

DIABETES & METABOLISM (2019)

添加到收藏夹

Article Gastroenterology & Hepatology

Association Between Nonalcoholic Fatty Liver Disease and Reduced Bone Mineral Density in Children: A Meta-Analysis

Alessandro Mantovani et al.

HEPATOLOGY (2019)

添加到收藏夹

Review Gastroenterology & Hepatology

Sex Differences in Nonalcoholic Fatty Liver Disease: State of the Art and Identification of Research Gaps

Amedeo Lonardo et al.

HEPATOLOGY (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Molecular Mechanism of Vitamin E as a Bone-Protecting Agent: A Review on Current Evidence

Sok Kuan Wong et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

添加到收藏夹

Review Medicine, General & Internal

Osteoporosis

Juliet E. Compston et al.

LANCET (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Hepatic OsteodystrophyMolecular Mechanisms Proposed to Favor Its Development

Sabrina Ehnert et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

添加到收藏夹

Article Endocrinology & Metabolism

Canagliflozin and fracture risk in individuals with type 2 diabetes: results from the CANVAS Program

Zien Zhou et al.

DIABETOLOGIA (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

Farnesoid X nuclear receptor agonists for the treatment of nonalcoholic steatohepatitis

Vasiliki Venetsanaki et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

添加到收藏夹

Review Gastroenterology & Hepatology

Systematic review with meta-analysis: non-alcoholic fatty liver disease is associated with a history of osteoporotic fractures but not with low bone mineral density

Alessandro Mantovani et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2019)

添加到收藏夹

Article Endocrinology & Metabolism

Association between non-alcoholic fatty liver disease and bone turnover biomarkers in post-menopausal women with type 2 diabetes

A. Mantovani et al.

DIABETES & METABOLISM (2019)

添加到收藏夹

Review Endocrinology & Metabolism

Off-label uses of denosumab in metabolic bone diseases

Stergios A. Polyzos et al.

BONE (2019)

添加到收藏夹

Article Endocrinology & Metabolism

Dual Targeting of Bile Acid Receptor-1 (TGR5) and Farnesoid X Receptor (FXR) Prevents Estrogen-Dependent Bone Loss in Mice

Zhenxi Li et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2019)

添加到收藏夹

Article Immunology

Circulatory pattern of cytokines, adipokines and bone markers in postmenopausal women with low BMD

Fawaz Y. Azizieh et al.

JOURNAL OF INFLAMMATION RESEARCH (2019)

添加到收藏夹

Article Endocrinology & Metabolism

The relationship between fatty liver index and bone mineral density in Koreans: KNHANES 2010-2011

S. H. Ahn et al.

OSTEOPOROSIS INTERNATIONAL (2018)

添加到收藏夹

Review Endocrinology & Metabolism

The association between liver cirrhosis and fracture risk: A systematic review and meta-analysis

Jie Liang et al.

CLINICAL ENDOCRINOLOGY (2018)

添加到收藏夹

Review Endocrinology & Metabolism

Denosumab vs bisphosphonates for the treatment of postmenopausal osteoporosis

Athanasios D. Anastasilakis et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2018)

添加到收藏夹

Review Gastroenterology & Hepatology

Current and future therapeutic regimens for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

Zobair M. Younossi et al.

HEPATOLOGY (2018)

添加到收藏夹

Review Endocrinology & Metabolism

Sarcopenic obesity

Stergios A. Polyzos et al.

HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (2018)

添加到收藏夹

Article Endocrinology & Metabolism

Tocotrienol supplementation suppressed bone resorption and oxidative stress in postmenopausal osteopenic women: a 12-week randomized double-blinded placebo-controlled trial

C-L Shen et al.

OSTEOPOROSIS INTERNATIONAL (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Nonalcoholic fatty liver disease with elevated alanine aminotransferase levels is negatively associated with bone mineral density: Cross-sectional study in US adults

Toshihiro Umehara

PLOS ONE (2018)

添加到收藏夹

Review Endocrinology & Metabolism

Pioglitazone Therapy and Fractures: Systematic Review and Meta-Analysis

Velichka Pavlova et al.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS (2018)

添加到收藏夹

Article Obstetrics & Gynecology

Association between nonalcoholic fatty liver disease and bone mineral density in postmenopausal women

Dong-Yun Lee et al.

CLIMACTERIC (2018)

添加到收藏夹

Article Endocrinology & Metabolism

The Combined Effect of Nonalcoholic Fatty Liver Disease and Metabolic Syndrome on Osteoporosis in Postmenopausal Females in Eastern China

Da-Zhi Chen et al.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (2018)

添加到收藏夹

Article Endocrinology & Metabolism

Association of Nonalcoholic Fatty Liver Disease With Osteoporotic Fractures: A Cross-Sectional Retrospective Study of Chinese Individuals

Yanmao Wang et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

添加到收藏夹

Article Medicine, General & Internal

Increased risk of osteoporosis in patients with nonalcoholic fatty liver disease A population-based retrospective cohort study

Hon-Jhe Chen et al.

MEDICINE (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Body fat has stronger associations with bone mass density than body mass index in metabolically healthy obesity

Yuan-Yuei Chen et al.

PLOS ONE (2018)

添加到收藏夹

Review Geriatrics & Gerontology

Novel insights into the relationship between nonalcoholic fatty liver disease and osteoporosis

Rafal Filip et al.

CLINICAL INTERVENTIONS IN AGING (2018)

添加到收藏夹

Article Medicine, Research & Experimental

Canagliflozin triggers the FGF23/1,25-dihydroxyvitamin D/PTH axis in healthy volunteers in a randomized crossover study

Jenny E. Blau et al.

JCI INSIGHT (2018)

添加到收藏夹

Article Endocrinology & Metabolism

Association between fibroblast growth factor 21 and bone mineral density in adults

Ruo-Han Hao et al.

ENDOCRINE (2018)

添加到收藏夹

Review Endocrinology & Metabolism

Irisin in metabolic diseases

Stergios A. Polyzos et al.

ENDOCRINE (2018)

添加到收藏夹

Review Endocrinology & Metabolism

Nonalcoholic fatty liver disease and osteoporosis: a systematic review and meta-analysis

Sikarin Upala et al.

JOURNAL OF BONE AND MINERAL METABOLISM (2017)

添加到收藏夹

Review Endocrinology & Metabolism

Mechanisms of diabetes mellitus-induced bone fragility

Nicola Napoli et al.

NATURE REVIEWS ENDOCRINOLOGY (2017)

添加到收藏夹

Article Gastroenterology & Hepatology

Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases

Leon A. Adams et al.

GUT (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Significant liver fibrosis assessed using liver transient elastography is independently associated with low bone mineral density in patients with non-alcoholic fatty liver disease

Gyuri Kim et al.

PLOS ONE (2017)

添加到收藏夹

Article Oncology

The farnesoid X receptor negatively regulates osteoclastogenesis in bone remodeling and pathological bone loss

Ting Zheng et al.

ONCOTARGET (2017)

添加到收藏夹

Article Endocrinology & Metabolism

Metabolically healthy/unhealthy components may modify bone mineral density in obese people

Atieh Mirzababaei et al.

ARCHIVES OF OSTEOPOROSIS (2017)

添加到收藏夹

Review Nutrition & Dietetics

Abdominal Obesity and Risk of Hip Fracture: A Systematic Review and Meta-Analysis of Prospective Studies

Omid Sadeghi et al.

ADVANCES IN NUTRITION (2017)

添加到收藏夹

Review Medicine, Research & Experimental

NAFLD as a Sexual Dimorphic Disease: Role of Gender and Reproductive Status in the Development and Progression of Nonalcoholic Fatty Liver Disease and Inherent Cardiovascular Risk

Stefano Ballestri et al.

ADVANCES IN THERAPY (2017)

添加到收藏夹

Review Endocrinology & Metabolism

A dipose tissue, obesity and non-alcoholic fatty liver disease

Stergios A. Polyzos et al.

MINERVA ENDOCRINOLOGICA (2017)

添加到收藏夹

Review Endocrinology & Metabolism

Obesity, Type 2 Diabetes and Bone in Adults

Jennifer S. Walsh et al.

CALCIFIED TISSUE INTERNATIONAL (2017)

添加到收藏夹

Article Endocrinology & Metabolism

The risk of osteoporosis in patients with liver cirrhosis: a meta-analysis of literature studies

Roberta Lupoli et al.

CLINICAL ENDOCRINOLOGY (2016)

添加到收藏夹

Article Endocrinology & Metabolism

Circulating sclerostin and Dickkopf-1 levels in patients with nonalcoholic fatty liver disease

Stergios A. Polyzos et al.

JOURNAL OF BONE AND MINERAL METABOLISM (2016)

添加到收藏夹

Article Gastroenterology & Hepatology

Association of nonalcoholic fatty liver disease with bone mineral density and serum osteocalcin levels in Korean men

Hae Jin Yang et al.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2016)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Natural Course of Non-Alcoholic Fatty Liver Disease

Luis Calzadilla Bertot et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

添加到收藏夹

Article Medicine, Research & Experimental

The association of liver fat content and serum alanine aminotransferase with bone mineral density in middle-aged and elderly Chinese men and postmenopausal women

Ming-Feng Xia et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2016)

添加到收藏夹

Article Endocrinology & Metabolism

Adipokines in in nonalcoholic fatty liver disease

Stergios A. Polyzos et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2016)

添加到收藏夹

Review Endocrinology & Metabolism

Adiponectin as a target for the treatment of nonalcoholic steatohepatitis with thiazolidinediones: A systematic review

Stergios A. Polyzos et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2016)

添加到收藏夹

Article Endocrinology & Metabolism

Administration of anti-receptor activator of nuclear factor-kappa B ligand (RANKL) antibody for the treatment of osteoporosis was associated with amelioration of hepatitis in a female patient with growth hormone deficiency: a case report

Ayumu Takeno et al.

BMC ENDOCRINE DISORDERS (2016)

添加到收藏夹

Article Endocrinology & Metabolism

Association between bone mineral density and nonalcoholic fatty liver disease in Korean adults

S. H. Lee et al.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2016)

添加到收藏夹

Review Gastroenterology & Hepatology

Role of NLRP3 Inflammasome in the Progression of NAFLD to NASH

Xingyong Wan et al.

CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2016)

添加到收藏夹

Article Gastroenterology & Hepatology

Raloxifene Ameliorates Liver Fibrosis of Nonalcoholic Steatohepatitis Induced by Choline-Deficient High-Fat Diet in Ovariectomized Mice

Fangqiong Luo et al.

DIGESTIVE DISEASES AND SCIENCES (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Anti-osteopontin monoclonal antibody prevents ovariectomy-induced osteoporosis in mice by promotion of osteoclast apoptosis

Bo Zhang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

添加到收藏夹

Article Endocrinology & Metabolism

Osteocalcin Protects Against Nonalcoholic Steatohepatitis in a Mouse Model of Metabolic Syndrome

Anisha A. Gupte et al.

ENDOCRINOLOGY (2014)

添加到收藏夹

Article Gastroenterology & Hepatology

IL-17 Signaling Accelerates the Progression of Nonalcoholic Fatty Liver Disease in Mice

Isaac T. W. Harley et al.

HEPATOLOGY (2014)

添加到收藏夹

Article Endocrinology & Metabolism

Novel Genetic Models of Osteoporosis by Overexpression of Human RANKL in Transgenic Mice

Vagelis Rinotas et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2014)

添加到收藏夹

Article Medicine, Research & Experimental

Is serum Interleukin-17 associated with early atherosclerosis in obese patients?

Giovanni Tarantino et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2014)

添加到收藏夹

Article Endocrinology & Metabolism

Osteocalcin Reverses Endoplasmic Reticulum Stress and Improves Impaired Insulin Sensitivity Secondary to Diet-Induced Obesity Through Nuclear Factor-κB Signaling Pathway

Bo Zhou et al.

ENDOCRINOLOGY (2013)

添加到收藏夹

Article Endocrinology & Metabolism

Sex steroids and sex hormone-binding globulin in postmenopausal women with nonalcoholic fatty liver disease

Stergios A. Polyzos et al.

HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus

Stefan Kiechl et al.

NATURE MEDICINE (2013)

添加到收藏夹

Article Toxicology

Raloxifene affects fatty acid oxidation in livers from ovariectomized rats by acting as a pro-oxidant agent

E. R. Martins-Maciel et al.

TOXICOLOGY LETTERS (2013)

添加到收藏夹

Review Biochemistry & Molecular Biology

Interactions among bone, liver, and adipose tissue predisposing to diabesity and fatty liver

Giovanni Musso et al.

TRENDS IN MOLECULAR MEDICINE (2013)

添加到收藏夹

Article Endocrinology & Metabolism

Low Bone Mineral Density in Chinese Adults with Nonalcoholic Fatty Liver Disease

Ran Cui et al.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (2013)

添加到收藏夹

Article Gastroenterology & Hepatology

Increased bone mineral density in patients with non-alcoholic steatohepatitis

Muhsin Kaya et al.

WORLD JOURNAL OF HEPATOLOGY (2013)

添加到收藏夹

Article Gastroenterology & Hepatology

NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease

Wing-Kin Syn et al.

GUT (2012)

添加到收藏夹

Article Endocrinology & Metabolism

Association between Nonalcoholic Fatty Liver Disease (NAFLD) and Osteoporotic Fracture in Middle-Aged and Elderly Chinese

Mian Li et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2012)

添加到收藏夹

Review Gastroenterology & Hepatology

Nonalcoholic Fatty Liver Disease Multimodal Treatment Options for a Pathogenetically Multiple-hit Disease

Stergios A. Polyzos et al.

JOURNAL OF CLINICAL GASTROENTEROLOGY (2012)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Inflammatory bone loss: pathogenesis and therapeutic intervention

Kurt Redlich et al.

NATURE REVIEWS DRUG DISCOVERY (2012)

添加到收藏夹

Article Gastroenterology & Hepatology

Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers

Dong-Xing Cao et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2012)

添加到收藏夹

Article Endocrinology & Metabolism

Association of nonalcoholic fatty liver disease with low bone mass in postmenopausal women

Seong-Su Moon et al.

ENDOCRINE (2012)

添加到收藏夹

Article Endocrinology & Metabolism

Osteopontin deficiency protects against obesity-induced hepatic steatosis and attenuates glucose production in mice

F. W. Kiefer et al.

DIABETOLOGIA (2011)

添加到收藏夹

Article Gastroenterology & Hepatology

Osteopontin is Induced by Hedgehog Pathway Activation and Promotes Fibrosis Progression in Nonalcoholic Steatohepatitis

Wing-Kin Syn et al.

HEPATOLOGY (2011)

添加到收藏夹

Review Physiology

Biology of Human Sodium Glucose Transporters

Ernest M. Wright et al.

PHYSIOLOGICAL REVIEWS (2011)

添加到收藏夹

Article Endocrinology & Metabolism

Zoledronic acid-induced transient hepatotoxicity in a patient effectively treated for Paget's disease of bone

S. A. Polyzos et al.

OSTEOPOROSIS INTERNATIONAL (2011)

添加到收藏夹

Article Endocrinology & Metabolism

Role of wingless tail signaling pathway in osteoporosis: an update of current knowledge

Athanasios D. Anastasilakis et al.

CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY (2011)

添加到收藏夹

Article Gastroenterology & Hepatology

Metabolic and histological features of non-alcoholic fatty liver disease patients with different serum alanine aminotransferase levels

V. W-S. Wong et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2009)

添加到收藏夹

Review Medicine, Research & Experimental

Nonalcoholic Fatty Liver Disease: The Pathogenetic Roles of Insulin Resistance and Adipocytokines

Stergios A. Polyzos et al.

CURRENT MOLECULAR MEDICINE (2009)

添加到收藏夹

Review Pharmacology & Pharmacy

RANKL inhibition for the management of patients with benign metabolic bone disorders

Athanasios D. Anastasilakis et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2009)

添加到收藏夹

Article Endocrinology & Metabolism

Impact of glucose-dependent insulinotropic peptide on age-induced bone loss

Ke-Hong Ding et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2008)

添加到收藏夹

Article Medicine, General & Internal

Selective estrogen receptor modulator raloxifene-associated aggravation of nonalcoholic steatohepatitis

Toshinari Takamura et al.

INTERNAL MEDICINE (2007)

添加到收藏夹

Article Endocrinology & Metabolism

Spared bone mass in rats treated with thyroid hormone receptor TR beta-selective compound GC-1

FRS Freitas et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2003)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.