期刊
DIABETES CARE
卷 45, 期 4, 页码 772-781出版社
AMER DIABETES ASSOC
DOI: 10.2337/dc21-0089
关键词
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资金
- Diabetes UK [AA/18/7/34219]
- University of Bristol
- U.K. Medical Research Council (MRC) [CH/F/20/90003]
- British Heart Foundation [R01DK107859]
- British Heart Foundation Chair in Cardiovascular Science and Clinical Epidemiology [107849/Z/15/Z]
- National Institutes of Health (NIH) [107849/A/15/Z]
- NIH [218495/Z/19/Z]
- Phyllis and Jerome Lyle Rappaport Massachusetts General Hospital Research Scholar Award - Establishing Excellence in England (E3)
- NIHR Senior Investigator [MR/P023576/1]
- Wellcome Trust
- de Pass Vice Chancellor's research fellow at the University of Bristol
- Excellence in England (E3) grant
- MRC programme grant
- [17/0005700]
- [NF-0616-10102]
- [R01DK105072]
- [MC_UU_00011/1 and MC_UU_00011/6]
- Wellcome Trust [218495/Z/19/Z] Funding Source: Wellcome Trust
This study suggests that frequent insomnia symptoms are associated with higher levels of glycated hemoglobin and may have a causal role in type 2 diabetes.
OBJECTIVETo examine the effects of sleep traits on glycated hemoglobin (HbA(1c)). RESEARCH DESIGN AND METHODSThis study triangulated evidence across multivariable regression (MVR) and one- (1SMR) and two-sample Mendelian randomization (2SMR) including sensitivity analyses on the effects of five self-reported sleep traits (i.e., insomnia symptoms [difficulty initiating or maintaining sleep], sleep duration, daytime sleepiness, napping, and chronotype) on HbA(1c) (in SD units) in adults of European ancestry from the UK Biobank (for MVR and 1SMR analyses) (n = 336,999; mean [SD] age 57 [8] years; 54% female) and in the genome-wide association studies from the Meta-Analyses of Glucose and Insulin-Related Traits Consortium (MAGIC) (for 2SMR analysis) (n = 46,368; 53 [11] years; 52% female). RESULTSAcross MVR, 1SMR, 2SMR, and their sensitivity analyses, we found a higher frequency of insomnia symptoms (usually vs. sometimes or rarely/never) was associated with higher HbA(1c) (MVR 0.05 SD units [95% CI 0.04-0.06]; 1SMR 0.52 [0.42-0.63]; 2SMR 0.24 [0.11-0.36]). Associations remained, but point estimates were somewhat attenuated after excluding participants with diabetes. For other sleep traits, there was less consistency across methods, with some but not all providing evidence of an effect. CONCLUSIONSOur results suggest that frequent insomnia symptoms cause higher HbA(1c) levels and, by implication, that insomnia has a causal role in type 2 diabetes. These findings could have important implications for developing and evaluating strategies that improve sleep habits to reduce hyperglycemia and prevent diabetes.
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