期刊
DIABETES & METABOLISM
卷 48, 期 5, 页码 -出版社
MASSON EDITEUR
DOI: 10.1016/j.diabet.2022.101350
关键词
Type 2 diabetes mellitus; Metformin; Bone; Bone mineral density; Osteoporosis
资金
- National Natural Science Founda-tion of China (NSFC) [81870563]
This study investigated the association between metformin and bone mineral density (BMD) in Chinese patients with type 2 diabetes mellitus (T2DM). The results showed that metformin use was associated with a lower prevalence of osteoporosis and osteopenia, especially in women. Metformin treatment was independently associated with higher BMD and a lower odds ratio of osteoporosis and low BMD.
Aims: To investigate the association between metformin and bone mineral density (BMD) in a large cohort of Chinese patients with type 2 diabetes mellitus (T2DM). Methods: A total of 11,458 T2DM patients aged & GE;40 years were included. Information on demographic, anthropometric and clinical characteristics was collected from medical records. BMD at lumbar spine (LS), femoral neck (FN), and total hip(TH) was assessed by dual-energy X-ray absorptiometry. Results: Overall prevalence of osteopenia and osteoporosis was 37.4% and 10.3%, and was lower in patients on metformin (34.6% vs 38.3% and 7.1% vs 11.3%, both p < 0.001). Patients who had a lower BMI, older age, and lower estimated glomerular filtration rate (eGFR), had more osteoporosis, lower BMD (osteoporosis or osteo-penia), and a lower T-score at LS, FN and TH. Metformin use and male sex was associated with a higher BMD. Metformin treatment was also independently associated with higher T-score at LS, FN and TH (b values of 0.120, 0.082 and 0.108; all p < 0.001), and lower odds ratio of osteoporosis (OR = 0.779, 95%CI: 0.648-0.937, p = 0.008) or low BMD (OR = 0.834, 95%CI: 0.752 -0.925, p = 0.001). However, when analyzed by sex, this association of a lower odds ratio for osteoporosis with metformin was only significant in women (OR= 0.775, 95% CI: 0.633-0.948; p = 0.013). Conclusions: Metformin treatment was associated with a higher T-score and a lower odds ratio of osteopenia and osteoporosis, especially in the female population, independent of age, BMI, and eGFR.(c) 2022 Elsevier Masson SAS. All rights reserved.
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