期刊
DEVELOPMENTAL NEUROSCIENCE
卷 44, 期 6, 页码 429-437出版社
KARGER
DOI: 10.1159/000523875
关键词
Collapse response mediator proteins; Cytoskeleton; Neurite; Signal pathway; Neurodegenerative diseases
资金
- National Natural Science Foundation of China [31660269]
- Natural Science Foundation of Guangxi Province [2021GXNSFAA075004, 2017GXNSFAA198003, 2016GXNSFBA380098]
- Research Projects for Postgraduates of Guilin Medical University [GYYK2021007]
- University One Thousand Key Youth Teachers Cultivation Program of Guangxi Province
This article reviews the recent literature on the biological characteristics and mechanisms of CRMPs in different neurodegenerative diseases.
Collapse response mediator proteins (CRMPs) are a family of cytoplasmic phosphorylated proteins, and the mechanism of action has always been the research focus of neurological diseases. Previous studies on the CRMPs family have revealed that CRMPs mediate the growth and development of neuronal cytoskeleton through different signaling pathways in the body. It plays an important role in neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and spinocerebellar ataxia, which has attracted the attention of researchers. This article reviews the recent literature on the biological characteristics and mechanisms of CRMPs in different neurodegenerative diseases. (c) 2022 S. Karger AG, Basel
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