期刊
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
卷 64, 期 9, 页码 1114-1122出版社
WILEY
DOI: 10.1111/dmcn.15195
关键词
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资金
- Victorian Government Operational Infrastructure Support Program
- Choice, Passion, Life
- Royal Children's Hospital Foundation
- Department of Health Western Australia
- Cerebral Palsy Alliance Research Foundation
- Australasian Cerebral Palsy Clinical Trials Network
- National Health and Medical Research Council [1144566]
- Women's and Children's Health Network
- Victorian Department of Health and Human Services
- Royal Darwin Hospital
- Tasmanian Department of Health
- Lorenzo and Pamela Galli Research Trust
- Novita
- St Giles
- National Health and Medical Research Council of Australia [1144566] Funding Source: NHMRC
The birth prevalence and severity of disabilities in Australian singletons with cerebral palsy have decreased between 1995 and 2014, indicating changes in prenatal and perinatal care.
Aim To investigate temporal trends in birth prevalence, disability severity, and motor type for singletons with prenatal or perinatally acquired cerebral palsy (CP). Method Numerator data, number of children with CP born a singleton between 1995 and 2014, confirmed at 5 years of age, were drawn from three state registers with population-level ascertainment. Birth prevalence estimates and 95% confidence intervals (CI) were calculated per 1000 singleton live births for the three states combined, overall, by gestational age group, by dichotomized disability severity, and spastic laterality. Poisson regression models were used to analyse trends. Using data from all eight registers, trends in the proportional distribution of CP subtypes overall and stratified by gestational age were examined. Results Birth prevalence of CP declined from 1.8 (95% CI 1.6-2.0) in 1995 to 1996 to 1.2 (95% CI 1.1-1.4) in 2013 to 2014 (average 5% per 2-year epoch, p 0.001). Declines in birth prevalence were observed across all gestational age groups with the largest decline in children born at <28 weeks (average 8% per epoch, p 0.001). Prevalence of moderate-severe disability declined for children born at <28 and >= 37 weeks (average 11% and 7% per epoch respectively, p < 0.001). The proportions of bilateral spastic CP declined (p < 0.001) at <28 weeks (p = 0.014) and >= 37 weeks (p < 0.001). The proportion of children with dyskinesia increased (28-31 weeks: p = 0.021, 32-36 weeks: p = 0.001, and >= 37 weeks: p < 0.001). Interpretation Birth prevalence of CP and moderate-severe disability (<28 and >= 37 weeks) declined in Australian singletons between 1995 and 2014, reflecting changes in prenatal and perinatal care over time.
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