4.7 Article

The immune environment of the mammary gland fluctuates during post-lactational regression and correlates with tumour growth rate

期刊

DEVELOPMENT
卷 149, 期 8, 页码 -

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COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.200162

关键词

Mammary gland; Involution; Immune cells; Tumourigenesis; Mouse

资金

  1. Medical Research Council project [MR/N022963/1]
  2. University of Cambridge

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Post-lactational mammary gland regression involves programmed cell death, ECM breakdown, and adipocyte redifferentiation. Tumor growth is impacted by the stage of involution at which cells are implanted in a syngeneic model. Older first-time mothers have increased breast cancer risk, with initial tumor growth faster in aged mice compared to young mice.
Post-lactational mammary gland regression encompasses extensive programmed cell death and removal of milk-producing epithelial cells, breakdown of extracellular matrix components and redifferentiation of stromal adipocytes. This highly regulated involution process is associated with a transient increased risk of breast cancer in women. Using a syngeneic tumour model, we show that tumour growth is significantly altered depending on the stage of involution at which tumour cells are implanted. Tumour cells injected at day 3 involution grew faster than those in nulliparous mice, whereas tumours initiated at day 6 involution grew significantly slower. These differences in tumour progression correlate with distinct changes in innate immune cells, in particular among F4/80-expressing macrophages and among TCR delta(+) unconventional T cells. Breast cancer post-pregnancy risk is exacerbated in older first-time mothers and, in our model, initial tumour growth is moderately faster in aged mice compared with young mice. Our results have implications for breast cancer risk and the use of anti-inflammatory therapeutics for postpartum breast cancers.

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