4.5 Article

Plasma secretome analyses identify IL-8 and nitrites as predictors of poor prognosis in nasopharyngeal carcinoma patients

期刊

CYTOKINE
卷 153, 期 -, 页码 -

出版社

ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2022.155852

关键词

Cytokine; IL-8; Nitric oxide; Nasopharyngeal carcinoma; Prognosis

资金

  1. Agence Thematique de Recherche Scientifique de la Sante et de la Vie (ATRSSV, Algeria)
  2. NIH/NCI Cancer Center Support Grant [P30 CA008748]
  3. Swim Across America
  4. Ludwig Institute for Cancer Research
  5. Ludwig Center for Cancer Immunotherapy at Memorial Sloan Kettering
  6. Cancer Research Institute
  7. Parker Institute for Cancer

向作者/读者索取更多资源

In this study, the plasmatic secretomes of NPC untreated and relapsing patients were analyzed to identify novel prognostic biomarkers. The results showed upregulation of certain cytokines in untreated and relapsing patients. There were also correlations found between different cytokines in different patient groups. The study suggests that the High IL-8/Low NO signature may be a predictor of poor prognosis for NPC patients.
Predicting tumor recurrence and death in patients with nasopharyngeal carcinoma (NPC) remains to date challenging. We here analyzed the plasmatic secretomes of NPC untreated and relapsing patients, and explored possible correlations with the clinical and pathological features and survival characteristics of the corresponding patient cohorts, with the aim of identifying novel prognostic biomarkers. This study included 27 controls, 45 untreated NPC and 11 relapsed patients. A set of 14 plasma cytokines were analyzed using Millipore multiplex assay. Nitrites were assessed by Griess method. A comparative analysis of each groups' secretome showed upregulation of IL-8, IL-12p70, IL-10 and IP-10 in untreated patients, and of IL-6, IL-10, MCP-1 and IP-10 in relapsing patients. Nitrites significantly correlated with IL-8 during relapse. Secretomes' network analyses revealed prevalence of high correlations between IL8/IL-17A and IFN-gamma/IL12p70 in the control group, between TNF-alpha/IL-8/IL-6, TNF-alpha/VEGF/IFN-gamma and IL-10/MCP-1 in the untreated group, and between IL-8/IL-6/IL-10, TNF-alpha/IL-8/IL-6, IL-12-p70/VEGF/IL-10/IFN-gamma, IL-6/IL-10/IFN-gamma and IL-8/IP-10 in the relapse group. IL 12p70, IP-10 and MCP-1 levels respectively associated with gender, age and node metastasis respectively. Recurrence-free survival (RFS) analysis showed that patients presenting High IL-8/Low NO immunological scores presented a combined 80% probability of relapse/death after 53 months (combined log-rank test p = 0.0034; individual p = 0.012 and p = 0.016). Multivariate Cox hazard regression analysis revealed that IL-8 (HR = 7.451; 95% CI [2.398-23.152]; p = 0.001) and treatment type (HR = 0.232; 95% CI 0.072-0.749; p = 0.015) were independent prognostic factors. C & RT decision tree analysis showed that High IL-8/Low NO immunological scores predicted treatment failure in 50% cases starting the 36th month of follow-up (AUC = 1) for all of the studied cases and in 57% cases for patients receiving chemotherapy alone (AUC = 1). Altogether, our results showed that NPC development is accompanied with cytokines deregulation to form specific interaction networks at time of diagnosis and relapse, and demonstrate that High IL-8/Low NO signature may constitute a predictor of poor prognosis which may be useful to improve risk stratification and therapy failure management.

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