期刊
CURRENT TOPICS IN MEDICINAL CHEMISTRY
卷 22, 期 12, 页码 1020-1034出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026622666220317162132
关键词
Ciprofloxacin; Hybrids; Antibacterial; Staphylococcus aureus; Structure-activity relationship; Methicillin-resistant
Staphylococcus aureus is a significant pathogen that can cause various infections. The emergence of drug-resistant S. aureus, particularly MRSA, has complicated treatment. Ciprofloxacin is an effective broad-spectrum antibacterial agent, but its overuse has led to the emergence of ciprofloxacin-resistant S. aureus. However, ciprofloxacin hybrids have the potential to overcome drug resistance by targeting multiple drug targets in bacteria. This review provides an overview of recent ciprofloxacin hybrids with anti-S. aureus potential, including their structure-activity relationships and mechanisms of action.
Staphylococcus aureus (S. aureus), an important pathogen of both humans and animals, can cause a variety of infections at any site of the body. The evolution of S. aureus resistance is notorious, and the widespread of drug-resistant S. aureus, especially methicillin-resistant S. aureus (MRSA), has made the treatment difficult in recent decades. Nowadays, S. aureus is among the leading causes of bacterial infections, creating an urgent need for the development of novel antibacterial agents. Ciprofloxacin, characterized by high clinical efficacy, is a broad-spectrum antibacterial agent with frequency of prescription for various Gram-positive and Gram-negative pathogens, many of which are resistant to a wide range of antibiotics. However, the long-term and widespread use of this antibiotic has led to the emergence of ciprofloxacin-resistant pathogens, and ciprofloxacin-resistant S. aureus has been noted in clinical practice. Ciprofloxacin hybrids have been recognized as advanced chemical entities to simultaneously modulate multiple drug targets in bacteria, so ciprofloxacin hybrids have the potential to overcome drug resistance. The present review provides an overview of ciprofloxacin hybrids with anti-S. aureus potential that has been reported in the last decade with an emphasis on their structure-activity relationships and mechanisms of action.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据