Chronic Thromboembolic Pulmonary Hypertension (CTEPH): A Review of Another Sequel of Severe Post-Covid-19 Pneumonia

The spectrum of pulmonary parenchymal and vascular pathologies related to the COVID-19 have emerged. There is evidence of a specific suscepti-bility related to thrombotic microangiopathy in situ and a complex immune-inflammatory cascade, espe-cially in the pulmonary vascular bed. The potential to lead to transient or self-correcting sequelae of pulmo-nary vascular injury will only become apparent with longer-term follow-up. In this review, we aimed to present the findings in a group of patients with severe pneumonia due to covid-19 complicated by acute pe documented by chest angiography, who during a follow-up of more than 3 months with oral anticoagu-lant met clinical, hemodynamic, and imaging criteria of chronic thromboembolic pulmonary hypertension. We present a brief review of the epidemiology, patho-physiology, clinical findings, comorbidities, treatment, and imaging findings of chronic thromboembolic pulmonary hypertension as a sequel of severe post-covid-19 pneumonia; and compared and discussed these findings with similar reports from the medical literature. (Curr Probl Cardiol 2023

Automated summary

This article discusses the spectrum of pulmonary parenchymal and vascular pathologies related to COVID-19. It highlights the specific susceptibility related to thrombotic microangiopathy and the complex immune-inflammatory cascade in the pulmonary vascular bed. The potential for long-term pulmonary vascular injury and its sequelae, particularly chronic thromboembolic pulmonary hypertension, requires further follow-up. The article provides a review of the epidemiology, pathophysiology, clinical findings, comorbidities, treatment, and imaging findings of chronic thromboembolic pulmonary hypertension as a sequel to severe post-COVID-19 pneumonia, comparing and discussing these findings with similar reports in the medical literature.