4.4 Article

N-acetyl Cysteine Inhibits Cell Proliferation and Differentiation of LPS-Induced MC3T3-E1 Cells Via Regulating Inflammatory Cytokines

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Summary: The study revealed that hyperlipidemia impairs osseointegration of titanium implants in mice and inhibits osteogenic differentiation of osteoblasts on titanium surface under high-fat conditions. Moreover, high-fat medium induces overproduction of reactive oxygen species and suppression of the Wnt/beta-catenin pathway in osteoblasts. N-acetyl-L-cysteine (NAC) and Wnt3a were found to mitigate the negative effects and reactivate the osteogenic ability of osteoblasts, suggesting potential therapeutic targets for improving osseointegration in hyperlipidemic patients.

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