期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 74, 期 -, 页码 -出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2022.102382
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资金
- Swiss National Science Foundation [310030 204373]
- Swiss National Science Foundation (SNF) [310030_204373] Funding Source: Swiss National Science Foundation (SNF)
Members of the LRRC8 family play a role in the response of vertebrate cells to changes in their environment. These proteins form complexes that function as ion channels activated during cell-swelling. This review summarizes the current understanding of the structure-function relationships of these ion channels, which are still poorly understood despite their physiological importance.
Members of the LRRC8 family participate in the response of vertebrate cells to osmotic changes in their environment. These proteins form heteromeric assemblies composed of the obligatory subunit LRRC8A and at least one of the other four homologs, which together function as anion-selective channels with distinct properties that are activated upon cell-swelling. The hexameric complexes share a conserved architecture consisting of a membrane-inserted pore domain with an ion permeation path located at the axis of symmetry and cytoplasmic leucine-rich repeat domains that regulate the open probability of the channel. In this review, we summarize the current understanding of structure-function relationships of these unusual ion channels whose mechanisms are, despite their large physiological importance, still poorly understood.
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