期刊
CURRENT OPINION IN PHARMACOLOGY
卷 63, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2022.102200
关键词
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资金
- Italian Ministry of Instruction, University and Research PRIN [20179JHAMZ_006]
- Ateneo 2020 Sapienza University of Rome [AR220172B2D1C4AE]
- FOE2020 (project title Nuovi biomarker diagnostici e terapeutici delle malattie neurodegenerative)
Herpes simplex virus-1 (HSV-1) can cause recurrent diseases and severe herpetic encephalitis. Neurodegenerative disorders (such as Alzheimer's disease) associated with HSV-1 infection may be prevented or treated with antiviral drugs or preventive strategies.
Herpes simplex virus-1 (HSV-1) is a ubiquitous DNA virus able to establish a life-long latent infection in host sensory ganglia. Following periodic reactivations, the neovirions usually target the site of primary infection causing recurrent diseases in susceptible individuals. However, reactivated HSV-1 may also reach the brain resulting in severe herpetic encephalitis or in asymptomatic infections. These have been reportedly linked to neurodegenerative disorders, such as Alzheimer's disease (AD), suggesting antiviral preventive or/therapeutic treatments as possible strategies to counteract AD onset and progression. Here, we provide an overview of the AD-like mechanisms driven by HSV-1-infection in neurons and discuss the ongoing trials repurposing anti-herpetic drugs to treat AD as well as preventive strategies aimed at blocking virus infection.
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