The true incidence of recurrent implantation failure

Review Cell Biology

Maternal selection of human embryos in early gestation: Insights from recurrent miscarriage

Jan J. Brosens et al.

Summary: Compared to other mammals, human pregnancy is unique in its involvement of chromosomally diverse embryos and the cyclical breakdown and regeneration of the uterine mucosa. Understanding the mechanisms behind miscarriage can provide insights into the maternal selection of embryos during early gestation.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2022)

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Article Obstetrics & Gynecology

Rate of true recurrent implantation failure is low: results of three successive frozen euploid single embryo transfers

Paul Pirtea et al.

Summary: The study retrospectively analyzed data from 4,429 women and found that the true recurrent implantation failure rate is low. For patients capable of producing euploid blastocysts, transferring three embryos can still achieve a high clinical pregnancy rate.

FERTILITY AND STERILITY (2021)

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Article Obstetrics & Gynecology

Definition, diagnostic and therapeutic options in recurrent implantation failure: an international survey of clinicians and embryologists

D. Cimadomo et al.

Summary: There is a wide variability in the definition, investigation, and therapy for recurrent implantation failure (RIF) worldwide, indicating the urgent need for clinical guidelines in this area.

HUMAN REPRODUCTION (2021)

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Review Obstetrics & Gynecology

Recurrent implantation failure: how common is it?

Paul Pirtea et al.

Summary: There is no universally accepted definition for repeated implantation failures (RIF) in women undergoing successive frozen euploid single embryo transfers (FE-SET) as of yet. Research findings indicate that RIF following three successive euploid embryo transfers in a morphologically normal endometrium is rare. Therefore, it is suggested that ART failures mainly result from embryonic causes.

CURRENT OPINION IN OBSTETRICS & GYNECOLOGY (2021)

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Article Obstetrics & Gynecology

An algorithm to personalise the diagnosis of recurrent implantation failure based on theoretical cumulative implantation rate

Genia Rozen et al.

Summary: RIF is a disorder with an imprecise definition lacking robust scientific basis, presenting significant challenges in diagnosis and treatment. The concept of 'Theoretical Cumulative Implantation Rate' is proposed to determine RIF diagnosis based on objective data. An updated and standardized definition is needed for patient counseling and research planning.

HUMAN REPRODUCTION (2021)

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Article Obstetrics & Gynecology

A new definition of recurrent implantation failure on the basis of anticipated blastocyst aneuploidy rates across female age

Baris Ata et al.

Summary: This study utilized mathematical modeling to explore the impact of female age and anticipated blastocyst euploidy rates on cumulative implantation rates. The results indicate that older patients require more blastocysts to achieve the desired cumulative implantation probability without preimplantation genetic testing. However, assuming an implantation rate of 55% for euploid blastocysts, only 4 blastocysts are needed to reach a cumulative probability rate greater than 95%, regardless of age.

FERTILITY AND STERILITY (2021)

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Review Obstetrics & Gynecology