4.5 Editorial Material

Editorial overview: Vaccines: Reinvigorating therapeutic cancer vaccines

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biotechnology & Applied Microbiology

Unannotated proteins expand the MHC-I-restricted immunopeptidome in cancer

Tamara Ouspenskaia et al.

Summary: Peptides originating from novel or unannotated open reading frames (nuORFs) detected by ribosome profiling can be displayed on MHC-I of cancer cells, serving as additional sources of cancer antigens. These nuORFs represent an unexplored pool of tumor-specific peptides with potential as immunotherapy targets.

NATURE BIOTECHNOLOGY (2022)

Review Biotechnology & Applied Microbiology

Identification of neoantigens for individualized therapeutic cancer vaccines

Franziska Lang et al.

Summary: This Review discusses the use of tumor-specific neoantigens in anticancer vaccines and introduces the mechanisms of neoantigen T cell recognition, as well as computational approaches to predict which neoantigens might confer proficient antitumor immunity in patients. Individualized treatment approaches are required to harness the full potential of the unique cancer mutations in each patient. Computational algorithms and machine-learning tools can be used to identify mutations, prioritize T cell-recognized antigens, and design personalized vaccines for each patient.

NATURE REVIEWS DRUG DISCOVERY (2022)

Article Biochemistry & Molecular Biology

Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses

Can Cui et al.

Summary: The study found that the enrichment of TFH cell transcriptional signature in lung adenocarcinoma patients is correlated with GC B cell signature and prolonged survival. Interactions between tumor-specific TFH and GC B cells are crucial for tumor control and effector CD8 T cell function.
Article Biochemistry & Molecular Biology

Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma

Zhuting Hu et al.

Summary: Personal neoantigen peptide vaccines induce long-lasting T cell responses in melanoma patients, broadening the spectrum of tumor-specific cytotoxicity and resulting in diverse T cell clones with cytotoxic gene signatures.

NATURE MEDICINE (2021)

Review Oncology

Advances in the development of personalized neoantigen-based therapeutic cancer vaccines

Eryn Blass et al.

Summary: Immunotherapy has revolutionized cancer treatment with the development of immune-checkpoint inhibitors and personalized neoantigen vaccines. These vaccines trigger specific T cell responses against individual patient's tumors, showing promising tumor-specific immunogenicity and antitumor activity.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Article Oncology

An Empirical Antigen Selection Method Identifies Neoantigens That Either Elicit Broad Antitumor T-cell Responses or Drive Tumor Growth

Hubert Lam et al.

Summary: The ATLAS bioassay is developed to identify neoantigens empirically by expressing patient-specific tumor mutations individually, revealing both stimulatory and inhibitory responses. Therapeutic immunization with stimulatory neoantigens protected animals, while immunization with inhibitory responses resulted in accelerated tumor growth. Empirical testing shows that T-cell responses to neoantigens are more nuanced than straightforward MHC antigen recognition and could impact cancer immunotherapy design.

CANCER DISCOVERY (2021)

Review Biochemistry & Molecular Biology

mRNA therapeutics in cancer immunotherapy

Jan D. Beck et al.

Summary: Synthetic mRNA serves as a versatile template for protein synthesis and has a wide range of pharmaceutical applications, including cancer immunotherapy. Strategies such as stimulating pattern recognition receptors and nucleoside modification enhance the effectiveness and safety of mRNA vaccines.

MOLECULAR CANCER (2021)

Article Multidisciplinary Sciences

A vaccine targeting mutant IDH1 in newly diagnosed glioma

Michael Platten et al.

Summary: Mutated isocitrate dehydrogenase 1 (IDH1) defines a molecularly distinct subtype of diffuse glioma. The most common IDH1 mutation in gliomas affects codon 132 and encodes IDH1(R132H), which harbours a shared clonal neoepitope that is presented on major histocompatibility complex (MHC) class II. An IDH1(R132H)-specific peptide vaccine (IDH1-vac) induces specific therapeutic T helper cell responses that are effective against IDH1(R132H)+ tumours.

NATURE (2021)

Article Immunology

Personalized cancer vaccine strategy elicits polyfunctional T cells and demonstrates clinical benefits in ovarian cancer

Janos L. Tanyi et al.

Summary: By adding ASA and low-dose IL-2 to the OCDC-Bev-Cy combination regimen, we elicited vaccine-specific T-cell responses that positively correlated with prolonged time-to-progression and overall survival in patients. This combinatorial strategy was effective and demonstrated the utility of the ID8 ovarian model for future ovarian trial development.

NPJ VACCINES (2021)

Article Multidisciplinary Sciences

Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers

Justina X. Caushi et al.

Summary: Single-cell RNA sequencing and T cell receptor sequencing are combined to identify transcriptional programs specific to mutation-associated neoantigen-specific T cells in non-small cell lung cancers treated with anti-PD-1, providing insights into resistance to PD-1 blockade.

NATURE (2021)

Article Multidisciplinary Sciences

Phenotype, specificity and avidity of antitumour CD8+ T cells in melanoma

Giacomo Oliveira et al.

Summary: The authors demonstrate through single-cell profiling and T cell receptor specificity screening that tumour antigen recognition influences the phenotypes of CD8(+) T cells and antitumour immune responses. Non-tumour-reactive T cells show a non-exhausted memory phenotype, while melanoma-reactive lymphocytes exhibit an exhausted state, providing insights into the properties of the anti-melanoma TCR repertoire.

NATURE (2021)

Review Biochemical Research Methods

High-throughput and single-cell T cell receptor sequencing technologies

Joy A. Pai et al.

Summary: This Review discusses methodological advances in high-throughput analysis of the TCR repertoire, particularly at single-cell resolution. Recent studies have developed high-throughput sequencing technologies to identify TCR sequences and analyze their antigen specificities, providing important insights into T cell-mediated immune responses.

NATURE METHODS (2021)

Article Oncology

Neoantigen vaccination induces clinical and immunologic responses in non-small cell lung cancer patients harboring EGFR mutations

Fenge Li et al.

Summary: The phase I trial of personalized NeoAg peptide vaccination in NSCLC patients showed feasibility and safety. Clinical and immune responses following vaccination suggest that EGFR mutations are shared, immunogenic neoantigens with promising therapeutic potential for NSCLC patients. PPV with concurrent EGFR inhibitor therapy was well tolerated and contributed to the induction of T cell responses.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Oncology

Phase I/II trial of a long peptide vaccine (LPV7) plus toll-like receptor (TLR) agonists with or without incomplete Freund's adjuvant (IFA) for resected high-risk melanoma

Sapna P. Patel et al.

Summary: This study evaluated the safety and immunogenicity of a novel long peptide vaccine with different adjuvants, showing that the LPV7 vaccine induced certain immune responses under various adjuvant strategies, but did not significantly enhance T cell responses compared to vaccines using short peptides.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Oncology

A machine learning model for ranking candidate HLA class I neoantigens based on known neoepitopes from multiple human tumor types

Jared J. Gartner et al.

Summary: Robbins and colleagues developed and tested a machine learning model for ranking tumor neoantigens, aiding in the identification of potential therapeutic targets for future immunotherapies. The model showed improved sensitivity and specificity by incorporating multiple factors impacting epitope presentation and recognition, compared to using predicted HLA binding alone. The ranked output provides a list of potential neoantigens for further in vitro and in vivo studies, facilitating the development of more effective immunotherapies.

NATURE CANCER (2021)

Review Immunology

T Cell Epitope Predictions

Bjoern Peters et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 38 (2020)

Article Immunology

Mutation position is an important determinant for predicting cancer neoantigens

Aude-Helene Capietto et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

Article Biotechnology & Applied Microbiology

A large peptidome dataset improves HLA class I epitope prediction across most of the human population

Siranush Sarkizova et al.

NATURE BIOTECHNOLOGY (2020)

Review Immunology

Computational Prediction and Validation of Tumor-Associated Neoantigens

Vladimir Roudko et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Oncology

Vaccination against Nonmutated Neoantigens Induced in Recurrent and Future Tumors

Greta Garrido et al.

CANCER IMMUNOLOGY RESEARCH (2020)

Article Multidisciplinary Sciences

An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma

Ugur Sahin et al.

NATURE (2020)

Article Medicine, Research & Experimental

mRNA vaccine-induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer

Gal Cafri et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Biochemistry & Molecular Biology

Shared Immunogenic Poly-Epitope Frameshift Mutations in Microsatellite Unstable Tumors

Vladimir Roudko et al.

Review Genetics & Heredity

Integrative single-cell analysis

Tim Stuart et al.

NATURE REVIEWS GENETICS (2019)

Review Immunology

Turning the corner on therapeutic cancer vaccines

Robert E. Hollingsworth et al.

NPJ VACCINES (2019)

Article Biochemistry & Molecular Biology

Immunogenic neoantigens derived from gene fusions stimulate T cell responses

Wei Yang et al.

NATURE MEDICINE (2019)

Article Multidisciplinary Sciences

MHC-II neoantigens shape tumour immunity and response to immunotherapy

Elise Alspach et al.

NATURE (2019)

Article Biotechnology & Applied Microbiology

Robust prediction of HLA class II epitopes by deep motif deconvolution of immunopeptidomes

Julien Racle et al.

NATURE BIOTECHNOLOGY (2019)

Review Immunology

Cancer Neoantigens

Ton N. Schumacher et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 37, 2019 (2019)

Article Multidisciplinary Sciences

Actively personalized vaccination trial for newly diagnosed glioblastoma

Norbert Hilf et al.

NATURE (2019)

Article Multidisciplinary Sciences

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

Derin B. Keskin et al.

NATURE (2019)

Article Biotechnology & Applied Microbiology

Deep learning using tumor HLA peptide mass spectrometry datasets improves neoantigen identification

Brendan Bulik-Sullivan et al.

NATURE BIOTECHNOLOGY (2019)

Review Immunology

Features of effective T Cell-inducing vaccines against Chronic viral infections

Eleni Panagioti et al.

FRONTIERS IN IMMUNOLOGY (2018)

Article Multidisciplinary Sciences

RNA editing derived epitopes function as cancer antigens to elicit immune responses

Minying Zhang et al.

NATURE COMMUNICATIONS (2018)

Article Cell Biology

Noncoding regions are the main source of targetable tumor-specific antigens

Celine M. Laumont et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

Article Multidisciplinary Sciences

An immunogenic personal neoantigen vaccine for patients with melanoma

Patrick A. Ott et al.

NATURE (2017)

Article Multidisciplinary Sciences

Mutant MHC class II epitopes drive therapeutic immune responses to cancer

Sebastian Kreiter et al.

NATURE (2015)

Review Oncology

Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy

Pierre G. Coulie et al.

NATURE REVIEWS CANCER (2014)

Article Multidisciplinary Sciences

Mutational heterogeneity in cancer and the search for new cancer-associated genes

Michael S. Lawrence et al.

NATURE (2013)

Article Multidisciplinary Sciences

Signatures of mutational processes in human cancer

Ludmil B. Alexandrov et al.

NATURE (2013)