Navigating the complexity of chronic HIV-1 associated immune dysregulation

Article Immunology

Time to Viral Rebound After Interruption of Modern Antiretroviral Therapies

Jonathan Z. Li et al.

Summary: Early initiation of antiretroviral therapy can significantly delay the time to HIV rebound after treatment interruption, lowering the barrier for HIV remission.

CLINICAL INFECTIOUS DISEASES (2022)

添加到收藏夹

Review Virology

Monocyte/Macrophage-Mediated Innate Immunity in HIV-1 Infection: From Early Response to Late Dysregulation and Links to Cardiovascular Diseases Onset

Eman Teer et al.

Summary: Monocytes and macrophages play crucial roles in the pathogenesis of HIV-1 infection, where the early host response can determine the nature of the infection. The expansion of monocyte subsets provides a deeper understanding of their role in chronic inflammation and increasing the risk of coagulation during HIV-1 infection.

VIROLOGICA SINICA (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Antigen-driven clonal selection shapes the persistence of HIV-1-infected CD4(+) T cells in vivo

Francesco R. Simonetti et al.

Summary: The study highlights that antigen-driven clonal selection plays a major role in HIV-1 persistence, posing a difficult challenge for eradication efforts. The research demonstrates a link between antigen responsiveness, proviral sequence, integration site, and TCR beta sequence in understanding the mechanisms behind maintaining the HIV-1 reservoir.

JOURNAL OF CLINICAL INVESTIGATION (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Chronic HIV infection induces transcriptional and functional reprogramming of innate immune cells

Wouter A. van der Heijden et al.

Summary: Chronic inflammation and immune dysfunction are important factors in the development of non-AIDS-related comorbidities. The study found that monocytes in PLHIV exhibit an exacerbated proinflammatory profile, potentially leading to long-term HIV complications.

JCI INSIGHT (2021)

添加到收藏夹

Article Immunology

Changes in NK Cell Subsets and Receptor Expressions in HIV-1 Infected Chronic Patients and HIV Controllers

Zhi Zhang et al.

Summary: This study compared the phenotypes of NK cells in subjects with chronic HIV-1 infection, HIV controllers, and healthy donors, showing that controllers had increased activating receptors expression and a higher number of CD56(+)/CD16(-) NK cell subset, along with higher levels of plasma cytokines. This suggests that higher immune activation in controllers may play a key role in killing and suppressing HIV compared to chronic patients.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Immunology

The Architecture of Circulating Immune Cells Is Dysregulated in People Living With HIV on Long Term Antiretroviral Treatment and Relates With Markers of the HIV-1 Reservoir, Cytomegalovirus, and Microbial Translocation

Lisa Van de Wijer et al.

Summary: This study revealed substantial differences in T and B cell composition and function in people living with HIV (PLHIV) on stable treatment compared to HIV-uninfected controls. The changes in various immune cell populations were influenced by host factors, markers of HIV reservoir, and CMV serostatus. Furthermore, alterations in circulating lymphocytes translated into functional changes with reduced IFN-gamma responses to specific stimuli.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Medicine, Research & Experimental

HIV-1 integration sites in CD4+ T cells during primary, chronic, and late presentation of HIV-1 infection

Yik Lim Kok et al.

Summary: Characteristics of HIV-1 integration sites are established as early as during primary infection and are found in both resting and activated CD4(+) T cells. HIV-1 integration sites preferentially occur in specific genes and highly expressed genes, regardless of the activation state of CD4(+) T cells. The preference for cancer-related genes is more prominent at later stages of HIV-1 infection.

JCI INSIGHT (2021)

添加到收藏夹

Article Microbiology

Germinal Center T follicular helper (GC-Tfh) cell impairment in chronic HIV infection involves c-Maf signaling

Marita Chakhtoura et al.

Summary: This study showed that HIV-infected individuals have distinctive gene expression patterns in GC-Tfh cells, which leads to impaired anti-HIV antibody responses. Downregulation of MAF and its upstream signaling pathway in HIV-infected subjects contributes to the dysfunction of GC-Tfh and GC-B cell functions. Supplementation with ADA-1 partially restored the impaired signaling in GC-Tfh cells during chronic infection.

PLOS PATHOGENS (2021)

添加到收藏夹

Article Immunology

TIGIT blockade enhances NK cell activity against autologous HIV-1-infected CD4+ T cells

Kayla A. Holder et al.

Summary: This study investigates the role of TIGIT in individuals living with HIV, revealing its expression on CD4(+) T cells, CD8(+) T cells, and NK cells, and its association with HIV-1 disease progression. Therapeutic targeting of TIGIT may enhance NK cell antibody-dependent cytotoxicity against HIV-1.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2021)

添加到收藏夹

Article Immunology

Differential transcriptional and functional properties of regulatory T cells in HIV-infected individuals on antiretroviral therapy and long-term non-progressors

Shima Shahbaz et al.

Summary: The study revealed that HIV infection affects the transcriptional profile and functional properties of Tregs, with differences between individuals receiving treatment and long-term non-progressors. These findings may explain the higher prevalence of autoimmune diseases in LTNPs. Furthermore, upregulation of HLA-F in Tregs of HIV-infected individuals highlights a potential role of this non-classical HLA in the context of HIV infection, warranting further investigation in other chronic viral infections and cancer.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2021)

添加到收藏夹

Article Immunology

Monocytes from men living with HIV exhibit heightened atherogenic potential despite long-term viral suppression with antiretroviral therapy

Thomas A. Angelovich et al.

AIDS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody

Philipp Schommers et al.

CELL (2020)

添加到收藏夹

Article Multidisciplinary Sciences

HIV-1 elite controllers present a high frequency of activated regulatory T and Th17 cells

Diogo G. Caetano et al.

PLOS ONE (2020)

添加到收藏夹

Review Immunology

Broadly neutralizing antibodies for the treatment and prevention of HIV infection

Marina Caskey

CURRENT OPINION IN HIV AND AIDS (2020)

添加到收藏夹

Review Microbiology

The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies

Lillian B. Cohn et al.

CELL HOST & MICROBE (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Plasmacytoid dendritic cells sense HIV replication before detectable viremia following treatment interruption

Julie L. Mitchell et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

添加到收藏夹

Article Infectious Diseases

Alterations of the frequency and functions of follicular regulatory T cells and related mechanisms in HIV infection

Shuang Zhao et al.

JOURNAL OF INFECTION (2020)

添加到收藏夹

Review Oncology

TIGIT in cancer immunotherapy

Joe-Marc Chauvin et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

添加到收藏夹

Review Immunology

Plasmacytoid dendritic cell biology and its role in immune-mediated diseases

Yishan Ye et al.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2020)

添加到收藏夹

Review Immunology

Innate Lymphoid Cells in Mucosal Immunity

Santosh K. Panda et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Article Immunology

Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses

Rachel L. Clement et al.

NATURE IMMUNOLOGY (2019)

添加到收藏夹

Review Immunology

T-Follicular Regulatory Cells: Potential Therapeutic Targets in Rheumatoid Arthritis

Tingting Ding et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Review Immunology

When worlds collide: Th17 and Treg cells in cancer and autoimmunity

Hannah M. Knochelmann et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2018)

添加到收藏夹

Article Immunology

mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3+ Regulatory T Cells

Im-Hong Sun et al.

JOURNAL OF IMMUNOLOGY (2018)

添加到收藏夹

Review Immunology

Follicular Dendritic Cells of Lymph Nodes as Human Immunodeficiency Virus/Simian Immunodeficiency Virus Reservoirs and Insights on Cervical Lymph Node

Rajnish S. Dave et al.

FRONTIERS IN IMMUNOLOGY (2018)

添加到收藏夹

Article Immunology

T Cell Subsets in the Germinal Center: Lessons from the Macaque Model

Monica Vaccari et al.

FRONTIERS IN IMMUNOLOGY (2018)

添加到收藏夹

Article Immunology

Follicular CD4 T Helper Cells As a Major HIV Reservoir Compartment: A Molecular Perspective

Malika Aid et al.

FRONTIERS IN IMMUNOLOGY (2018)

添加到收藏夹

Article Immunology

Expression of the Inhibitory Receptor TIGIT Is Up-Regulated Specifically on NK Cells With CD226 Activating Receptor From HIV-Infected Individuals

Xiaowan Yin et al.

FRONTIERS IN IMMUNOLOGY (2018)

添加到收藏夹

Article Biochemical Research Methods

Prediction of HIV-1 sensitivity to broadly neutralizing antibodies shows a trend towards resistance over time

Anna Hake et al.

PLOS COMPUTATIONAL BIOLOGY (2017)

添加到收藏夹

Review Immunology

The Role of CD4+T Follicular Helper Cells in HIV Infection: From the Germinal Center to the Periphery

John Patrick Thornhill et al.

FRONTIERS IN IMMUNOLOGY (2017)

添加到收藏夹

Article Immunology

BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency

Behdad Afzali et al.

NATURE IMMUNOLOGY (2017)

添加到收藏夹

Review Microbiology

What Integration Sites Tell Us about HIV Persistence

Stephen H. Hughes et al.

CELL HOST & MICROBE (2016)

添加到收藏夹

Review Biochemistry & Molecular Biology

TFH in HIV Latency and as Sources of Replication-Competent Virus

Brodie Miles et al.

TRENDS IN MICROBIOLOGY (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

HIV-1 Integration Landscape during Latent and Active Infection

Lillian B. Cohn et al.

CELL (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection

Brodie Miles et al.

NATURE COMMUNICATIONS (2015)

添加到收藏夹

Review Immunology

Monocytes as Regulators of Inflammation and HIV-Related Comorbidities during cART

Joshua J. Anzinger et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2014)

添加到收藏夹

Review Immunology

Systemic Effects of Inflammation on Health during Chronic HIV Infection

Steven G. Deeks et al.

IMMUNITY (2013)

添加到收藏夹

Article Medicine, Research & Experimental

HIV-1 Pathogenesis: The Virus

Ronald Swanstrom et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)

添加到收藏夹

Review Oncology

CCR6 as a mediator of immunity in the lung and gut

Toshihiro Ito et al.

EXPERIMENTAL CELL RESEARCH (2011)

添加到收藏夹

Article Immunology

Regulation of the Germinal Center Reaction by Foxp3+ Follicular Regulatory T Cells

Ivonne Wollenberg et al.

JOURNAL OF IMMUNOLOGY (2011)

添加到收藏夹

Article Public, Environmental & Occupational Health

HIV infection and aging of the innate immune system

Anna C. Hearps et al.

SEXUAL HEALTH (2011)

添加到收藏夹

Review Immunology

CD56bright natural killer (NK) cells: an important NK cell subset

Aurelie Poli et al.

IMMUNOLOGY (2009)

添加到收藏夹

Article Immunology

Lymphoid follicles are sites of heightened human immunodeficiency virus type 1 (HIV-1) replication and reduced antiretroviral effector mechanisms

JM Folkvord et al.

AIDS RESEARCH AND HUMAN RETROVIRUSES (2005)

添加到收藏夹

Article Immunology

Impact of highly active anti-retroviral therapy (HAART) on cytokine production and monocyte subsets in HIV-infected patients

N Amirayan-Chevillard et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2000)

添加到收藏夹

Navigating the complexity of chronic HIV-1 associated immune dysregulation

相关参考文献

导出引文

分享论文