4.5 Review

Factors that influence singlet oxygen formation vs. ligand substitution for light-activated ruthenium anticancer compounds

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ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2022.102143

关键词

Photodynamic therapy; Photoactivated chemotherapy; Photodissocia-tion; Photosubstitution; Photochemistry; Ruthenium; Anticancer; Protic; ligands; Diimine ligands

资金

  1. NIH [R15-GM132803-01]

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This review discusses light-activated ruthenium anticancer compounds and the factors that influence the preferred pathway. Photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) are two main light-activated treatment methods, which depend on the electronic properties of ligands and the characteristics of metal complexes.
This review focuses on light-activated ruthenium anticancer compounds and the factors that influence which pathway is favored. Photodynamic therapy (PDT) is favored by p expansion and the presence of low-lying triplet excited states (e.g. (MLCT)-M-3, (IL)-I-3). Photoactivated chemotherapy (PACT) refers to light-driven ligand dissociation to give a toxic metal complex or a toxic ligand upon photo substitution. This process is driven by steric bulk near the metal center and weak metal-ligand bonds to create a low-energy 3MC state with antibonding character. With protic dihydroxybipyridine ligands, ligand charge can play a key role in these processes, with a more electron-rich deprotonated ligand favoring PDT and an electron-poor protonated ligand favoring PACT in several cases.

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