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Molecular probes for fluorescence image-guided cancer surgery

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ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2021.102112

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  1. World-leading Innovative Graduate Study Program for Life Science and Technology (WINGS-LST) [JP19H05632, JP19H02826, JP20H05724]
  2. MEXT/JSPS KAKENHI

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In this article, we reviewed the use of molecular probes for fluorescence image-guided cancer surgery, with a focus on recent advancements in high-performance tumor imaging probes and their design strategies.
In cancer surgery, complete surgical resection of tumor lesions is critical to optimize the outcome. However, it is sometimes difficult to distinguish the boundary between tumor and normal tissues, and residual tumor tissue can result in cancer recurrence. Intraoperative imaging with fluorescent molecular probes can assist surgeons to visualize tumor lesions and their boundaries during surgery. Here, we review molecular probes for fluorescence image-guided cancer surgery, focusing especially on recent developments in high-performance tumor-imaging probes and the strategies used for their design.

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