期刊
CURRENT OPINION IN CELL BIOLOGY
卷 75, 期 -, 页码 -出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2022.02.007
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资金
- Wellcome Trust [220082/Z/20/Z]
- Royal Society [213470/Z/18/Z]
- Wellcome Trust [220082/Z/20/Z, 213470/Z/18/Z] Funding Source: Wellcome Trust
The actin and microtubule cytoskeletons in mammalian oocytes and zygotes have distinct forms at various subcellular locations, allowing for different functions within the same cell. Recent discoveries, aided by tools such as light-sensitive microscopy assays, have shed light on the form and function of these cytoskeletons in female reproductive cell biology. These findings include unexpected involvement of F-actin in oocyte chromosome segregation, oocyte-specific spindle self-organization modes, and the existence of nuclear actin polymers with emerging functions. Functional actin-microtubule interactions have also been identified as crucial for mammalian embryo development. Additionally, age-related changes in chromosome structure and dynamics that increase the risk of aneuploidy in mammalian eggs have been uncovered.
The actin and microtubule cytoskeletons of mammalian oocytes and zygotes exist in distinct forms at various subcellular locations. This enables each cytoskeletal system to perform vastly different functions in time and space within the same cell. In recent years, key discovery enabling tools including light-sensitive microscopy assays have helped to illuminate cytoskeletal form and function in female reproductive cell biology. New findings include unexpected participation of F-actin in oocyte chromosome segregation, oocyte specific modes of spindle self-organization as well as existence of nuclear actin polymers whose functions are only starting to emerge. Functional actin-microtubule interactions have also been identified as an important feature that supports mammalian embryo development. Other advances have revealed reproductive age-related changes in chromosome structure and dynamics that predispose mammalian eggs to aneuploidy.
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