期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 74, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2021.10.016
关键词
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资金
- ERC Starting Grant (STROFUNSCAF)
- ERC Proof-of-Concept Grant (MINGRAFT)
- Medical Research Council (UK Regenerative Medicine Platform Hub Acellular Smart Materials 3D Architecture) [MR/R015651/1]
The field of biofabrication has the potential to advance with the incorporation of biological assembling mechanisms into fabrication techniques. Biological organization principles such as self-assembly, compartmentalization, diffusion-reaction, disorder-to-order transitions, and out-of-equilibrium processes play a crucial role in tissue and organ formation. These approaches have shown promise in improving scalability, reproducibility, vascularization, and biomimicry in biofabrication.
The field of biofabrication continues to progress, offering higher levels of spatial control, reproducibility, and functionality. However, we remain far from recapitulating what nature has achieved. Biological systems such as tissues and organs are assembled from the bottom-up through coordinated supramolecular and cellular processes that result in their remarkable structures and functionalities. In this perspective, we propose that incorporating such biological assembling mechanisms within fabrication techniques, offers an opportunity to push the boundaries of biofabrication. We dissect these mechanisms into distinct biological organization principles (BOPs) including self-assembly, compartmentalization, diffusion-reaction, disorder-to-order transitions, and out-of-equilibrium processes. We highlight recent work demonstrating the viability and potential of these approaches to enhance scalability, reproducibility, vascularization, and biomimicry; as well as current challenges to overcome.
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