4.6 Review

Netrin-1 in Post-stroke Neuroprotection: Beyond Axon Guidance Cue

期刊

CURRENT NEUROPHARMACOLOGY
卷 20, 期 10, 页码 1879-1887

出版社

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1570159X20666220302150723

关键词

Netrin-1; angiogenesis; apoptosis; autophagy; neuroinflammation; neuroprotection; cerebral ischemia

资金

  1. National Natural Science Foundation of China [82071366]
  2. National Natural Scientific Foundation of Guangdong, China [2019A1515011600]
  3. Southern China International Cooperation Base for Early Intervention and Functional Rehabilitation of Neurological Diseases [2015B05050 1003]
  4. Guangdong Provincial Engineering Center for Major Neurological Disease Treatment
  5. Guangdong Provincial Translational Medicine Innovation Platform for Diagnosis and Treatment of Major Neurological Disease
  6. Guangdong Provincial Clinical Research Center for Neurological Diseases

向作者/读者索取更多资源

In this review, the neuroprotective function of Netrin-1 and its possibly involved pathways after ischemic stroke are discussed, providing a basis for the development of novel treatments.
Background: Stroke, especially ischemic stroke, is a leading disease associated with death and long-term disability with limited therapeutic options. Neuronal death caused by vascular impairment, programmed cell death and neuroinflammation has been proven to be associated with increased stroke severity and poor stroke recovery. In light of this, a development of neuroprotective drugs targeting injured neurons is urgently needed for stroke treatment. Netrin-1, known as a bifunctional molecule, was originally described to mediate the repulsion or attraction of axonal growth by interacting with its different receptors. Importantly, accumulating evidence has shown that netrin-1 can manifest its beneficial functions to brain tissue repair and neural regeneration in different neurological disease models. Objective: In this review, we focus on the implications of netrin-1 and its possibly involved pathways on neuroprotection after ischemic stroke, through which a better understanding of the underlying mechanisms of netrin-1 may pave the way to novel treatments. Methods Peer-reviewed literature was recruited by searching databases of PubMed, Scopus, Embase, and Web of Science till the year 2021. Conclusion: There has been certain evidence to support the neuroprotective function of netrin-1 by regulating angiogenesis, autophagy, apoptosis and neuroinflammation after stroke. Netrin-1 may be a promising drug candidate in reducing stroke severity and improving outcomes.

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