The Dissemination of NDM-1 in Acinetobacter baumannii Strains

Acinetobacter baumannii is a common pathogen in hospitals and usually causes bacteremia, pneumonia, meningitis, peritonitis and other diseases. Isolates carried NDM-1 gene can make several antibiotics such as carbapenems and other beta-lactams ineffective. Nowadays, the number of A. baumannii strains carrying NDM-1 has been climbing year by year in recent years. To characterise the transmission of NDM-1 in A. baumannii, we collected 2576 human-derived genomes of A. baumannii strains from NCBI database and found that 186 strains contained NDM-1 gene. The multi-locus sequence typing, phylogenetic tree, NDM-1 gene organization and the single nucleotide polymorphisms of NDM-1 were investigated. We hope that our work will provide a theoretical basis for the prevention of dissemination of NDM-1 in A. baumannii.

Automated summary

Acinetobacter baumannii is a common hospital pathogen that has been increasing in strains carrying the NDM-1 gene. Through investigating 186 strains with the NDM-1 gene, this study aims to provide a theoretical basis for preventing the dissemination of NDM-1 in A. baumannii.