Metallic Nanoparticles: A New Frontier in the Fight Against Leishmaniasis

Leishmaniasis, a cutaneous, mucocutaneous, or visceral parasitic disease caused by the protozoa of the genus Leishmania, is responsible for approximately 20-40 thousand deaths annually, with Brazil, India, and certain countries in Africa being the most affected. In addition to the parasite's ability to evade the host's immune system, the incidence of vectors, genetics of different hosts, and several deaths are attributed to the limited conventional treatments that have high toxicity, low effectiveness, and prolonged therapeutic regimens. Thus, the development of new alternative therapeutic strategies remains warranted. Metallic nanoparticles, such as gold, silver, zinc oxide, and titanium dioxide, have shown promising therapeutic tools since they are easily prepared and chemically modified, have a broad spectrum of action and low toxicity, and can generate reactive oxygen species and other immune responses. This review explores the progress of the use of metallic nanoparticles as new tools in the treatment of leishmaniasis and discusses the gaps in knowledge hindering the development of a safe and effective therapeutic intervention against these infections.

Automated summary

Leishmaniasis, a parasitic disease caused by Leishmania protozoa, is responsible for thousands of deaths annually. Conventional treatments have limitations, prompting the search for new therapeutic strategies. Metallic nanoparticles have shown promise as they can be easily prepared, have a broad spectrum of action and low toxicity. This review explores the progress and gaps in knowledge regarding metallic nanoparticles as new tools in leishmaniasis treatment.