Giant mobile elements: Agents of multivariate phenotypic evolution in fungi

Article Biochemistry & Molecular Biology

A large transposable element mediates metal resistance in the fungus Paecilomyces variotii

Andrew S. Urquhart et al.

Summary: Horizontal transfer of mobile elements is important for prokaryotic adaptation to environmental stresses, and a similar role may exist in eukaryotic microbes. In fungi, a large region called HEPHAESTUS (Hf) has been discovered, which confers tolerance to multiple metal/metalloid ions. Hf is mobile within the fungus genome and contains a high number of beneficial genes. These findings suggest that eukaryotic mobile elements may play a role in the transfer of large regions of beneficial DNA, similar to bacteria.

CURRENT BIOLOGY (2022)

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Article Biology

Translational demand is not a major source of plasmid-associated fitness costs

Jeronimo Rodriguez-Beltran et al.

Summary: Limiting translation efficiency does not increase the fitness costs of plasmids, suggesting that ribosomal paucity is not a major driver of plasmid fitness costs.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2022)

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Article Microbiology

Genome-Wide Analyses of Repeat-Induced Point Mutations in the Ascomycota

Stephanie van Wyk et al.

Summary: The RIP mutation pathway is a fungus-specific defense mechanism that introduces cytosine to thymine transitions in targeted sequences. Through genome-wide analysis in Ascomycota, it was found that most fungi had RIP mutations, especially in the Pezizomycotina classes. Extreme cases of RIP were limited to certain classes like Dothideomycetes and Sordariomycetes, while no evidence of RIP was found in Taphrinomycotina and Saccharomycotina genomes. Losses in RIP combined with controlled TE proliferation in certain groups may lead to genome enlargement and sub-genomic compartments.

FRONTIERS IN MICROBIOLOGY (2021)

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Article Biochemistry & Molecular Biology

The Enterprise, a massive transposon carrying Spok meiotic drive genes

Aaron A. Vogan et al.

Summary: The study reports the discovery of a giant tyrosine-recombinase-mobilized DNA transposon named Enterprise, and the finding that the Spok block not only has meiotic driving ability but also transposition capability. Additionally, experimental evidence demonstrates the deleterious effects of the Spok block in Podospora.

GENOME RESEARCH (2021)

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Article Biochemistry & Molecular Biology