期刊
CURRENT BIOLOGY
卷 32, 期 13, 页码 2834-+出版社
CELL PRESS
DOI: 10.1016/j.cub.2022.04.090
关键词
-
资金
- Institute for Basic Science in Korea [IBSR015-D1]
This study reveals that the anterior cingulate cortex (ACC) is part of the abnormal circuit changes in chronic pain and its downstream circuits are closely related to modulating sensorimotor integration and generating active movement. The projection from the ACC to the dorsolateral and lateral parts of the periaqueductal gray (dl/lPAG) enhances both reflexive and active avoidance behavior towards pain.
Although pain-related excessive fear is known to be a key factor in chronic pain disability, which involves the anterior cingulate cortex (ACC), little is known about the downstream circuits of the ACC for fear avoidance in pain processing. Using behavioral experiments and functional magnetic resonance imaging with optoge-netics at 15.2 T, we demonstrate that the ACC is a part of the abnormal circuit changes in chronic pain and its downstream circuits are closely related to modulating sensorimotor integration and generating active movement rather than carrying sensory information. The projection from the ACC to the dorsolateral and lateral parts of the periaqueductal gray (dl/lPAG) especially enhances both reflexive and active avoidance behavior toward pain. Collectively, our results indicate that increased signals from the ACC to the dl/lPAG might be critical for excessive fear avoidance in chronic pain disability.
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