期刊
CRYSTAL GROWTH & DESIGN
卷 22, 期 5, 页码 2946-2953出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.cgd.1c01401
关键词
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资金
- Dodd-Walls Centre for Photonic and Quantum Technologies
Spatially offset low-frequency Raman spectroscopy (SOLFRS) was used to investigate the surface-driven isothermal dehydration of model tablets containing citric acid monohydrate. Multivariate curve resolution and complementary Raman microscopy analysis were employed to interpret the SOLFRS data and obtain detailed information on the spatial dehydration characteristics within the tablets.
Surface-driven isothermal dehydration of model tablets containing citric acid monohydrate was investigated using spatially offset low-frequency Raman spectroscopy (SOLFRS). Experiments were carried out under different isothermal conditions (50 to 65 degrees C), and dehydration kinetics were monitored ex situ by sampling the tablets at different time points. Better SOLFRS data interpretation was facilitated by the use of multivariate curve resolution and complementary Raman microscopy analysis of tablet cross sections that enabled access to detailed information on spatial dehydration characteristics within the tablets. Additionally, theoretical characterization of Raman-active low-energy (phonon) modes of citric acid solid-state forms was carried out using periodic boundary density functional theory.
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