期刊
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
卷 174, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2022.103698
关键词
Malignant mesothelioma; Cancer stem cells; Chemoresistance
The high mortality rate of malignant pleural mesothelioma has led to the study of chemoresistance mechanisms, with the CSC model explaining this phenomenon. Identifying CSCs has potential to lead to new treatment methods.
The high mortality rate of malignant pleural mesothelioma led to study the mechanisms for chemoresistance. The cancer stem cell (CSC) model has been proposed to explain chemoresistance. CSCs are characterized by self-renewal capacity, that is detected through tumor-initiating cell assays. As in other malignancies, many studies sought to identify surface markers to isolate CSCs from malignant mesothelioma. Other studies characterized malignant mesothelioma CSCs for the expression of specific genes involved in stemness and the expression of proteins involved in chemoresistance. However, the main methods to characterize isolated CSCs include sphere formation, invasiveness, tumor-initiating capacity and expression of specific surface markers. The better knowledge of malignant mesothelioma CSCs allowed exploring new potential targets to develop specific treatments.
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