The chemistry, processing, and preclinical anti-hyperuricemia potential of tea: a comprehensive review

Hyperuricemia is an abnormal purine metabolic disease that occurs when there is an excess of uric acid in the blood, associated with cardiovascular diseases, hypertension, gout, and renal disease. Dietary intervention is one of the most promising strategies for preventing hyperuricemia and controlling uric acid concentrations. Tea (Camellia sinensis) is known as one of the most common beverages and the source of dietary polyphenols. However, the effect of tea on hyperuricemia is unclear. Recent evidence shows that a lower risk of hyperuricemia is associated with tea intake. To better understand the anti-hyperuricemia effect of tea, this review first briefly describes the pathogenesis of hyperuricemia and the processing techniques of different types of tea. Next, the epidemiological and experimental studies of tea and its bioactive compounds on hyperuricemia in recent years were reviewed. Particular attention was paid to the anti-hyperuricemia mechanisms targeting the hepatic uric acid synthase, renal uric acid transporters, and intestinal microbiota. Additionally, the desirable intake of tea for preventing hyperuricemia is provided. Understanding the anti-hyperuricemia effect and mechanisms of tea can better utilize it as a preventive dietary strategy. Highlights High purine diet, excessive alcohol/fructose consumption, and less exercise/sleep are the induction factors of hyperuricemia. Tea and tea compounds showed alleviated effects for hyperuricemia, especially polyphenols. Tea (containing caffeine or not) is not associated with a higher risk of hyperuricemia. Xanthine oxidase inhibition (reduce uric acid production), Nrf2 activation, and urate transporters regulation (increase uric acid excretion) are the potential molecular targets of anti-hyperuricemic effect of tea. About 5 g tea intake per day may be beneficial for hyperuricemia prevention.

Automated summary

This review explores the anti-hyperuricemia effect and mechanisms of tea. Tea intake is associated with a lower risk of hyperuricemia, especially polyphenols. Tea exhibits alleviating effects on hyperuricemia by inhibiting uric acid production, activating Nrf2, and regulating uric acid transporters. A desirable tea intake of about 5 g/day may be beneficial for preventing hyperuricemia.