期刊
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
卷 63, 期 20, 页码 4217-4234出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10408398.2022.2059441
关键词
Glucosinolates; isothiocyanates; metabolic fate; host health; application strategy
Glucosinolates and their metabolites from Brassicaceae plants have anti-inflammatory effects and undergo biotransformation to isothiocyanates in the intestine. Isothiocyanates have significant anti-inflammatory, anti-cancer, anti-obesity, and neuroprotective properties. However, environmental factors can affect the biotransformation process, resulting in less desirable derivatives of glucosinolates.
Glucosinolates and their metabolites from Brassicaceae plants have received widespread attention due to their anti-inflammatory effects. Glucosinolates occurs an enterohepatic circulation in the body, and the glucosinolates metabolism mainly happens in the intestine. Glucosinolates can be converted into isothiocyanates by intestinal bacteria, which are active substances with remarkable anti-inflammatory, anti-cancer, anti-obesity and neuroprotective properties. This biotransformation can greatly improve the bioactivities of glucosinolates. However, multiple factors in the environment can affect the biotransformation to isothiocyanates, including acidic pH, ferrous ions and thiocyanate-forming protein. The derivatives of glucosinolates under those conditions are usually nitriles and thiocyanates, which may impair the potential health benefits. In addition, isothiocyanates are extremely unstable because of an active sulfhydryl group, which limits their applications. This review mainly summarizes the classification, synthesis, absorption, metabolism, physiological functions and potential application strategies of glucosinolates and their metabolites.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据