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Biodistribution of the novel anticancer drug sodium trans-Retrachloridobis(1H-indazole)ruthenate(III)] KP-1339/IT139 in nude BALB/c mice and implications on its mode of action
Anna K. Bytzek et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2016)
Synthesis, characterization, antiproliferative and molecular docking study of new half sandwich Ir(III), Rh(III) and Ru(II) complexes
Saravanan Thangavel et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2016)
Ruthenium(II) polypyridyl complexes with 1,8-naphthalimide group as DNA binder, photonuclease, and dual inhibitors of topoisomerases I and IIα
Yanmei Sun et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2016)
Photo-induced DNA cleavage and cytotoxicity of a ruthenium(II) arene anticancer complex
Viktor Brabec et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2016)
Ru(II)/clotrimazole/diphenylphosphine/bipyridine complexes: Interaction with DNA, BSA and biological potential against tumor cell lines and Mycobacterium tuberculosis
Legna Colina-Vegas et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2016)
The studies on the cytotoxicity in vitro, cellular uptake, cell cycle arrest and apoptosis-inducing properties of ruthenium methylimidazole complex [Ru(MeIm)4(p-cpip)]2+
Lan-mei Chen et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2016)
Synthesis, characterization and biological activities of some Ru(II) complexes with substituted chalcones and their applications as chemotherapeutics against breast cancer
Ashok K. Singh et al.
JOURNAL OF MOLECULAR STRUCTURE (2016)
Inhibition of cancer cell growth by ruthenium complexes
Joji Iida et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2016)
Recent Advances on Dark and Light-Activated Cytotoxity of Imidazole-Containing Ruthenium Complexes
Ping Liu et al.
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2016)
Tricarbonylrhenium(I) complexes with 2-acetylpyridine-derived hydrazones are cytotoxic to NCI-H460 human large cell lung cancer
Camila Vargas Garcia et al.
NEW JOURNAL OF CHEMISTRY (2016)
The water soluble ruthenium(II) organometallic compound [Ru(p-cymene)(bis(3,5 dimethylpyrazol-1-yl)methane)Cl]Cl suppresses triple negative breast cancer growth by inhibiting tumor infiltration of regulatory T cells
Maura Montani et al.
PHARMACOLOGICAL RESEARCH (2016)
Synthesis, cytotoxicity in vitro, apoptosis, cell cycle arrest and comet assay of asymmetry ruthenium(II) complexes
Cheng Zhang et al.
POLYHEDRON (2016)
Use of 1,2,4-triazolo[1,5-a]pyrimidines to design new piano-stool ruthenium(II) compounds
Iwona Lakomska et al.
POLYHEDRON (2016)
Synthesis, structures, and DNA and protein binding of ruthenium(II)-p-cymene complexes of substituted pyridylimidazo[1,5-a] pyridine: enhanced cytotoxicity of complexes of ligands appended with a carbazole moiety
Themmila Khamrang et al.
RSC ADVANCES (2016)
Light-sensitive ruthenium complex-loaded cross-linked polymeric nanoassemblies for the treatment of cancer
Matthew Dickerson et al.
JOURNAL OF MATERIALS CHEMISTRY B (2016)
Antimetastatic activity of novel ruthenium (III) pyridine complexes
Liwei Gu et al.
CANCER MEDICINE (2016)
New 4′-(4-chlorophenyl)-2,2′:6′,2″-terpyridine ruthenium(II) complexes: Synthesis, characterization, interaction with DNA/BSA and cytotoxicity studies
Milan M. Milutinović et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2016)
Novel mononuclear ruthenium(II) complexes as potent and low-toxicity antitumour agents: synthesis, characterization, biological evaluation and mechanism of action
Pengchao Hu et al.
RSC ADVANCES (2016)
Highly Charged Ruthenium(II) Polypyridyl Complexes as Lysosome-Localized Photosensitizers for Two-Photon Photodynamic Therapy
Huaiyi Huang et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
Synthesis, characterization and catalytic, cytotoxic and antimicrobial activities of two novel cyclotriphosphazene-based multisite ligands and their Ru(II) complexes
Digdem Erdener Cirali et al.
APPLIED ORGANOMETALLIC CHEMISTRY (2015)
Ruthenium(II) polypyridyl complexes as mitochondria-targeted two-photon photodynamic anticancer agents
Jiangping Liu et al.
BIOMATERIALS (2015)
Cyclometalated Ruthenium(II) Anthraquinone Complexes Exhibit Strong Anticancer Activity in Hypoxic Tumor Cells
Leli Zeng et al.
CHEMISTRY-A EUROPEAN JOURNAL (2015)
A Cytostatic Ruthenium(II)-Platinum(II) Bis(terpyridyl) Anticancer Complex That Blocks Entry into SPhase by Up-regulating p27KIP1
Vadde Ramu et al.
CHEMISTRY-A EUROPEAN JOURNAL (2015)
Two novel BODIPY-Ru(II) arene dyads enabling effective photo-inactivation against cancer cells
Tianji Wang et al.
DALTON TRANSACTIONS (2015)
Synthesis, characterization and biological evaluation of mixed-ligand ruthenium(II) complexes for photodynamic therapy
Huaiyi Huang et al.
DALTON TRANSACTIONS (2015)
Unexpected DNA binding properties with correlated downstream biological applications in mono vs. bis-1,8-naphthalimide Ru(II)-polypyridyl conjugates
Gary J. Ryan et al.
DALTON TRANSACTIONS (2015)
Lipophilicity-dependent ruthenium N-heterocyclic carbene complexes as potential anticancer agents
Gaochao Lv et al.
DALTON TRANSACTIONS (2015)
Ruthenium(II)-arene complexes with naphthalimide-tagged N,O- and N,N-chelating ligands: Synthesis and biological evaluation
Kesete Ghebreyessus et al.
INORGANICA CHIMICA ACTA (2015)
Interaction of rhenium(I) complex carrying long alkyl chain with Calf Thymus DNA: Cytotoxic and cell imaging studies
Gopalakrishnan Balakrishnan et al.
INORGANICA CHIMICA ACTA (2015)
Antitumor activity of a rhenium (I)-diselenoether complex in experimental models of human breast cancer
Philippe Collery et al.
INVESTIGATIONAL NEW DRUGS (2015)
Synthesis, characterization and DNA-binding properties of Ru(II) complexes coordinated by ofloxacin as potential antitumor agents
Chengxi Wang et al.
JOURNAL OF COORDINATION CHEMISTRY (2015)
The key role of coligands in novel ruthenium(II)-cyclopentadienyl bipyridine derivatives: Ranging from non-cytotoxic to highly cytotoxic compounds
Leonor Corte-Real et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2015)
Selective nuclei accumulation of ruthenium(II) complex enantiomers that target G-quadruplex DNA
Dongdong Sun et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2015)
The 1,3-diaryltriazenido(p-cymene)ruthenium(II) complexes with a high in vitro anticancer activity
Jure Vajs et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2015)
Ruthenium(II) p-cymene complex bearing 2,2′-dipyridylamine targets caspase 3 deficient MCF-7 breast cancer cells without disruption of antitumor immune response
Goran N. Kaluderovic et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2015)
Modulating the Anticancer Activity of Ruthenium(II)-Arene Complexes
Catherine M. Clavel et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Novel C,N-Cyclometalated Benzimidazole Ruthenium(II) and Iridium(III) Complexes as Antitumor and Antiangiogenic Agents: A Structure-Activity Relationship Study
Jyoti Yellol et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Synthesis, DNA binding and photocleavage, and cellular uptake of an alkyl chain-linked dinuclear ruthenium(II) complex
Ping Liu et al.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2015)
Synthesis, characterization and anticancer activity of dinuclear ruthenium(II) complexes linked by an alkyl chain
Yan Zhang et al.
NEW JOURNAL OF CHEMISTRY (2015)
Isostructural Re(I)/Tc-99m(I) tricarbonyl complexes for cancer theranostics
Patrique Nunes et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2015)
A novel class of ruthenium-based photosensitizers effectively kills in vitro cancer cells and in vivo tumors
Jamie Fong et al.
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES (2015)
A Family of Potent Ru(II) Photosensitizers with Enhanced DNA Intercalation: Bimodal Photokillers
Eleftherios K. Pefkianakis et al.
PHOTOCHEMISTRY AND PHOTOBIOLOGY (2015)
Synthesis, characterization, crystal structure, cytotoxicity, apoptosis and cell cycle arrest of ruthenium(II) complex [Ru(bpy)2(adpa)](PF6)2 (bpy=2,2′-bipyridine, adpa=4-(4-aminophenyl)diazenyl-N-(pyridin-2-ylmethylene)aniline)
Yan Zhang et al.
RSC ADVANCES (2015)
Reactivity of hexanuclear ruthenium metallaprisms towards nucleotides and a DNA decamer
Lydia E. H. Paul et al.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2015)
Thermodynamic Investigations of [(phen)2Ru(tatpp)Ru(phen)2]4+ Interactions with B-DNA
Vu H. Le et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2015)
Organoiridium Complexes: Anticancer Agents and Catalysts
Zhe Liu et al.
ACCOUNTS OF CHEMICAL RESEARCH (2014)
Recent Advances in Multinuclear Complexes as Potential Anticancer and DNA Binding Agents
Kehua Wang et al.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2014)
Targeting DNA damage response in cancer therapy
Noriko Hosoya et al.
CANCER SCIENCE (2014)
Dinuclear [{(p-cym)RuCl}2(μ-phpy)](PF6)2 and heterodinuclear [(PPY)2Ir(μ-phpy)Ru(p-cym)Cl](PF6)2 complexes: synthesis, structure and anticancer activity
Suman Kumar Tripathy et al.
DALTON TRANSACTIONS (2014)
Cisplatin in cancer therapy: Molecular mechanisms of action
Shaloam Dasari et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2014)
Rhodium, Iridium, and Ruthenium Half-Sandwich Picolinamide Complexes as Anticancer Agents
Zahra Almodares et al.
INORGANIC CHEMISTRY (2014)
Metallomics insights into the programmed cell death induced by metal-based anticancer compounds
Cai-Ping Tan et al.
METALLOMICS (2014)
Multinuclear ruthenium(II) complexes as anticancer agents
Anil K. Gorle et al.
NEW JOURNAL OF CHEMISTRY (2014)
Potent Half-Sandwich Iridium(III) Anticancer Complexes Containing C∧I-Chelated and Pyridine Ligands
Zhe Liu et al.
ORGANOMETALLICS (2014)
NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application
Robert Trondl et al.
CHEMICAL SCIENCE (2014)
Organometallic Iridium(III) Anticancer Complexes with New Mechanisms of Action: NCI-60 Screening, Mitochondrial Targeting, and Apoptosis
Jessica M. Hearn et al.
ACS CHEMICAL BIOLOGY (2013)
Predicting small molecule fluorescent probe localization in living cells using QSAR modeling. 2. Specifying probe, protocol and cell factors; selecting QSAR models; predicting entry and localization
R. W. Horobin et al.
BIOTECHNIC & HISTOCHEMISTRY (2013)
Predicting small molecule fluorescent probe localization in living cells using QSAR modeling. 1. Overview and models for probes of structure, properties and function in single cells
R. W. Horobin et al.
BIOTECHNIC & HISTOCHEMISTRY (2013)
A near-infrared dye based on BODIPY for tracking morphology changes in mitochondria
Na Jiang et al.
CHEMICAL COMMUNICATIONS (2013)
Targeting Mitochondrial DNA with a Platinum-Based Anticancer Agent
Simon P. Wisnovsky et al.
CHEMISTRY & BIOLOGY (2013)
Bioactive iridium and rhodium complexes as therapeutic agents
Chung-Hang Leung et al.
COORDINATION CHEMISTRY REVIEWS (2013)
Chiral ruthenium(II) complexes with phenolic hydroxyl groups as dual poisons of topoisomerases I and II alpha
Pingyu Zhang et al.
DALTON TRANSACTIONS (2013)
Synthesis, characterization and in vitro anticancer activity of highly cytotoxic trithiolato diruthenium complexes of the type [(η6-p-MeC6H4iPr)2Ru2(μ2-SR1)2(μ2-SR2)]+ containing different thiolato bridges
Federico Giannini et al.
JOURNAL OF ORGANOMETALLIC CHEMISTRY (2013)
The induction of mitochondria-mediated apoptosis in cancer cells by ruthenium(II) asymmetric complexes
Chen Qian et al.
METALLOMICS (2013)
Targeting the endoplasmic reticulum with a membraneinteractive luminescent ruthenium(II) polypyridyl complex
Martin R. Gill et al.
CHEMICAL SCIENCE (2013)
Ruthenium(II) polypyridyl complexes and DNA-from structural probes to cellular imaging and therapeutics
Martin R. Gill et al.
CHEMICAL SOCIETY REVIEWS (2012)
Cytotoxicity and cellular impact of dinuclear organoiridium DNA intercalators and nucleases with long rigid bridging ligands
Mhd. Ali Nazif et al.
DALTON TRANSACTIONS (2012)
Rhodium(III) and iridium(III) complexes as anticancer agents
Yvonne Geldmacher et al.
INORGANICA CHIMICA ACTA (2012)
Chemistry of DNA minor groove binding agents
Gul Shahzada Khan et al.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2012)
Molecular and Cellular Characterization of the Biological Effects of Ruthenium(II) Complexes Incorporating 2-Pyridyl-2-pyrimidine-4-carboxylic Acid
Vanessa Pierroz et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Natural product DNA major groove binders
Paris L. Hamilton et al.
NATURAL PRODUCT REPORTS (2012)
Minimizing the damage: repair pathways keep mitochondrial DNA intact
Lawrence Kazak et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
Naphthalimide-Tagged Ruthenium-Arene Anticancer Complexes: Combining Coordination with Intercalation
Kelly J. Kilpin et al.
ORGANOMETALLICS (2012)
Redox, Spectroscopic, and Photophysical Properties of Ru-Pt Mixed-Metal Complexes Incorporating 4,7-Diphenyl-1,10-phenanthroline as Efficient DNA Binding and Photocleaving Agents
Samantha L. H. Higgins et al.
INORGANIC CHEMISTRY (2011)
Correlation Between Cellular Localization and Binding Preference to RNA, DNA, and Phospholipid Membrane for Luminescent Ruthenium(II) Complexes
Maria Matson et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2011)
Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?
Shankar Balasubramanian et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
Coordination-Driven Self-Assembly and Anticancer Activity of Molecular Rectangles Containing Octahedral Ruthenium Metal Centers
Vaishali Vajpayee et al.
ORGANOMETALLICS (2011)
Synthesis, Characterization and Anticancer Activity of Porphyrin-Containing Organometallic Cubes
Nicolas P. E. Barry et al.
AUSTRALIAN JOURNAL OF CHEMISTRY (2010)
Ruthenium-based chemotherapeutics: are they ready for prime time?
Emmanuel S. Antonarakis et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2010)
Anticancer activity of opened arene ruthenium metalla-assemblies
Nicolas P. E. Barry et al.
DALTON TRANSACTIONS (2010)
The status of platinum anticancer drugs in the clinic and in clinical trials
Nial J. Wheate et al.
DALTON TRANSACTIONS (2010)
Ruthenium(II)-arene complexes with functionalized pyridines: Synthesis, characterization and cytotoxic activity
Sanja Grguric-Sipka et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)
Nuclear Permeable Ruthenium(II)β-Carboline Complexes Induce Autophagy To Antagonize Mitochondrial-Mediated Apoptosis
Caiping Tan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
High-Fidelity Hydrophilic Probe for Two-Photon Fluorescence Lysosomal Imaging
Xuhua Wang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
A Ruthenium-Containing Organometallic Compound Reduces Tumor Growth through Induction of the Endoplasmic Reticulum Stress Gene CHOP
Xiangjun Meng et al.
CANCER RESEARCH (2009)
A Cytotoxic Ruthenium Tris(Bipyridyl) Complex that Accumulates at Plasma Membranes
Olivier Zava et al.
CHEMBIOCHEM (2009)
Anticancer activity of multinuclear arene ruthenium complexes coordinated to dendritic polypyridyl scaffolds
Preshendren Govender et al.
JOURNAL OF ORGANOMETALLIC CHEMISTRY (2009)
A ruthenium(II) polypyridyl complex for direct imaging of DNA structure in living cells
Martin R. Gill et al.
NATURE CHEMISTRY (2009)
Influence of the Arene Ligand, the Number and Type of Metal Centers, and the Leaving Group on the in Vitro Antitumor Activity of Polynuclear Organometallic Compounds
Maria G. Mendoza-Ferri et al.
ORGANOMETALLICS (2009)
KP1019, A New Redox-Active Anticancer Agent - Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients
Christian G. Hartinger et al.
CHEMISTRY & BIODIVERSITY (2008)
Therapeutic nanoparticles for drug delivery in cancer
Kwangjae Cho et al.
CLINICAL CANCER RESEARCH (2008)
Luminescent biological probes derived from ruthenium(II) estradiol polypyridine complexes
Kenneth Kam-Wing Lo et al.
INORGANIC CHEMISTRY (2008)
The ruthenium(II)-arene compound RAPTA-C induces apoptosis in EAC cells through mitochondrial and p53-JNK pathways
Soumya Chatterjee et al.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2008)
Remarkable anticancer activity of triruthenium-arene clusters compared to tetraruthenium-arene clusters
Bruno Therrien et al.
JOURNAL OF CLUSTER SCIENCE (2007)
Lysosomes: fusion and function
J. Paul Luzio et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
The resurgence of platinum-based cancer chemotherapy
Lloyd Kelland
NATURE REVIEWS CANCER (2007)
Methods to explore cellular uptake of ruthenium complexes
Cindy A. Puckett et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
A phase 2 trial of the liposomal DACH platinum L-NDDP in patients with therapy-refractory advanced colorectal cancer
Tomislav Dragovich et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2006)
From bench to bedside -: preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A)
Christian G. Hartinger et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2006)
Ruthenium half-sandwich complexes bound to protein kinase Pim-1
JE Debreczeni et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2006)
Characterization by NMR spectroscopy, X-ray analysis and cytotoxic activity of the ruthenium(II) compounds [RuL3](PF6)2 (L=2-phenylazopyridine or o-tolylazopyridine) and [RuL′2L](PF6)2 (L′, L=2-phenylazopyridine, 2,2′-bipyridine)
ACG Hotze et al.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY (2005)
In vitro and in vivo evaluation of ruthenium(II)-arene PTA complexes
C Scolaro et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Investigation of the role of Bax, p21/Waf1 and p53 as determinants of cellular responses in HCT116 colorectal cancer cells exposed to the novel cytotoxic ruthenium(II) organometallic agent, RM175
RL Hayward et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2005)
Development of organometallic (organo-transition metal) pharmaceuticals
CS Allardyce et al.
APPLIED ORGANOMETALLIC CHEMISTRY (2005)
A phase I and pharmacological study with imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a novel ruthenium anticancer agent
JM Rademaker-Lakhai et al.
CLINICAL CANCER RESEARCH (2004)
Cytotoxic α-halogenoacrylic derivatives of distamycin A and congeners
I Beria et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Multi-nuclear platinum complexes as anti-cancer drugs
NJ Wheate et al.
COORDINATION CHEMISTRY REVIEWS (2003)
Influence of chemical stability on the activity of the antimetastasis ruthenium compound NAMI-A
G Sava et al.
EUROPEAN JOURNAL OF CANCER (2002)
Inhibition of cancer cell growth by ruthenium(II) arene complexes
RE Morris et al.
JOURNAL OF MEDICINAL CHEMISTRY (2001)
Lobaplatin: a new antitumour platinum drug
MJ McKeage
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2001)
TiIV uptake and release by human serum transferrin and recognition of TiIV-transferrin by cancer cells:: Understanding the mechanism of action of the anticancer drug titanocene dichloride
ML Guo et al.
BIOCHEMISTRY (2000)
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