期刊
JAPANESE JOURNAL OF APPLIED PHYSICS
卷 55, 期 7, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.7567/JJAP.55.07LG04
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资金
- JSPS KAKENHI Grant [24108004, 25293390, 15J01427]
- Knowledge-based Medical Device Cluster/Miyagi Area
- Grants-in-Aid for Scientific Research [24108004, 16K13708, 16K12863, 25293390, 16H05520, 15J01427] Funding Source: KAKEN
As factors that influence cell membrane permeabilization during direct and indirect atmospheric-pressure plasma irradiation, charged particle influx, superoxide anion radicals (O-2(-)center dot), and hydrogen peroxide (H2O2) in plasma-irradiated solution were evaluated. These are the three strong candidate factors and might multiply contribute to cell membrane permeabilization. In particular, a shorter plasma diffusion distance leads to the enhancement of the direct effects such as charged particle influx and further increase cell membrane permeability. In addition, O-2(-)center dot dissipates over time (a life span of the order of minutes) in plasma-irradiated water, and the deactivation of a plasma-irradiated solution in term of cell membrane permeabilization occurs in a life span of the same order. These results could promote the understanding of the mechanism of plasma-induced cell membrane permeabilization. (C) 2016 The Japan Society of Applied Physics
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