4.7 Article

Crystal structure of Acetyl-CoA carboxylase (AccB) from Streptomyces antibioticus and insights into the substrate-binding through in silico mutagenesis and biophysical investigations

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Mechanism of biotin carboxylase inhibition by ethyl 4-[[2-chloro-5-(phenylcarbamoyl)phenyl]sulphonylamino]benzoate

Matthew K. Craft et al.

Summary: The rise of antibacterial-resistant bacteria is a major problem globally, requiring novel antibacterial agents to combat. Acetyl-CoA carboxylase (ACC) is a validated target, and SABA1 represents a potentially new class of antibiotics that can be used to combat the antibacterial resistance crisis.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2022)

Article Biochemistry & Molecular Biology

Structures of LnmK, a Bifunctional Acyltransferase/Decarboxylase, with Substrate Analogues Reveal the Basis for Selectivity and Stereospecificity

Lee M. Stunkard et al.

Summary: The study reveals that LnmK enzyme uses substrate-assisted catalysis to carry out decarboxylation and acyl transfer reactions, providing support for the biosynthesis of polyketides. The molecular structures of substrate analogues bound to LnmK help in understanding substrate specificity, stereospecificity, and catalytic mechanism, showcasing the potential of these analogues in studying enzymes with complex structure-function relationships.

BIOCHEMISTRY (2021)

Article Cell Biology

Higher infectivity of the SARS-CoV-2 new variants is associated with K417N/T, E484K, and N501Y mutants: An insight from structural data

Abbas Khan et al.

Summary: The new variants of SARS-CoV-2 are more contagious and require further investigation on their interaction with the host receptor to identify new therapeutic options. Specific mutations in the Spike glycoprotein of the new variants may play a critical role in their unique pathogenicity.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

Article Medicine, Research & Experimental

Inhibition of acetyl-CoA carboxylase by PP-7a exerts beneficial effects on metabolic dysregulation in a mouse model of diet-induced obesity

Tianya Liu et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2020)

Article Biochemistry & Molecular Biology

Structural insights into the mechanism of RNA recognition by the N-terminal RNA-binding domain of the SARS-CoV-2 nucleocapsid phosphoprotein

Abbas Khan et al.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2020)

Review Pharmacology & Pharmacy

Acetyl-CoA carboxylase (ACC) as a therapeutic target for metabolic syndrome and recent developments in ACC1/2 inhibitors

Leyuan Chen et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2019)

Article Biochemistry & Molecular Biology

mCSM-NA: predicting the effects of mutations on protein-nucleic acids interactions

Douglas E. V. Pires et al.

NUCLEIC ACIDS RESEARCH (2017)

Article Biochemistry & Molecular Biology

Crystal structure of the essential biotin-dependent carboxylase AccA3 from Mycobacterium tuberculosis

Matthew Bennett et al.

FEBS OPEN BIO (2017)

Article Biochemistry & Molecular Biology

Regulation and structure of the heteromeric acetyl-CoA carboxylase

Matthew J. Salie et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2016)

Review Pharmacology & Pharmacy

The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities

Samuel Genheden et al.

EXPERT OPINION ON DRUG DISCOVERY (2015)

Article Chemistry, Medicinal

Design, Synthesis, and Antibacterial Properties of Dual-Ligand Inhibitors of Acetyl-CoA Carboxylase

Molly A. Silvers et al.

JOURNAL OF MEDICINAL CHEMISTRY (2014)

Article Chemistry, Physical

Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 2. Explicit Solvent Particle Mesh Ewald

Romelia Salomon-Ferrer et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2013)

Review Biochemistry & Molecular Biology

Chemical Genetics of Acetyl-CoA Carboxylases

Xuyu Zu et al.

MOLECULES (2013)

Review Microbiology

Fatty acid biosynthesis in actinomycetes

Gabriela Gago et al.

FEMS MICROBIOLOGY REVIEWS (2011)

Article Multidisciplinary Sciences

A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore

J. Richard Miller et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biochemistry & Molecular Biology

Alanine scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity

Shane M. Simonsen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Acetyl-coenzyme A carboxylases: Versatile targets for drug discovery

Liang Tong et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2006)

Article Multidisciplinary Sciences

Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis

TW Lin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Review Chemistry, Multidisciplinary

The Amber biomolecular simulation programs

DA Case et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2005)

Review Biochemistry & Molecular Biology

Acetyl-coenzyme A carboxylase: crucial metabolic enzyme and attractive target for drug discovery

L Tong

CELLULAR AND MOLECULAR LIFE SCIENCES (2005)

Review Pharmacology & Pharmacy

Treating the metabolic syndrome: acetyl-CoA carboxylase inhibition

HJ Harwood

EXPERT OPINION ON THERAPEUTIC TARGETS (2005)

Article Physics, Multidisciplinary

Predicting crystal structures:: The Parrinello-Rahman method revisited -: art. no. 075503

R Martonák et al.

PHYSICAL REVIEW LETTERS (2003)

Article Biochemistry & Molecular Biology

Kinetic and structural analysis of a new group of acyl-CoA carboxylases found in Streptomyces coelicolor A3(2)

L Diacovich et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biotechnology & Applied Microbiology

Role of an essential acyl coenzyme A carboxylase in the primary and secondary metabolism of Streptomyces coelicolor A3(2)

E Rodríguez et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2001)

Review Biochemistry & Molecular Biology

Combinatorial alanine-scanning

KL Morrison et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2001)