期刊
COMPUTERS IN BIOLOGY AND MEDICINE
卷 143, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.compbiomed.2021.104948
关键词
Esophagus; Stomach; Peristalsis; Fluid-structure interaction; Immersed boundary method; Incompressible multiphase flow; Biomechanics
类别
资金
- Office of the Provost
- Office for Research
- Northwestern University Information Technology
- National Science Foundation [ACI-1548562]
In recent decades, in silico modeling has greatly enhanced our understanding of the physiology and biomechanics of organ systems. However, there has been a lack of high-fidelity models for the upper gastrointestinal tract. In this study, we present a detailed numerical model of the upper gastrointestinal tract that incorporates the fiber architecture of the muscle walls and simulates various digestive processes. The model can be used to investigate acid reflux and explore surgical strategies for obesity.
Over the past few decades, in silico modeling of organ systems has significantly furthered our understanding of their physiology and biomechanical function. In spite of the relative importance of the digestive system in normal functioning of the human body, there is a scarcity of high-fidelity models for the upper gastrointestinal tract including the esophagus and the stomach. In this work, we present a detailed numerical model of the upper gastrointestinal tract that not only accounts for the fiber architecture of the muscle walls, but also the multi-phasic components they help transport during normal digestive function. Construction details for 3D models of representative stomach geometry are presented along with a simple strategy for assigning circular and longi-tudinal muscle fiber orientations for each layer. We developed a fully resolved model of the stomach to simulate gastric peristalsis by systematically activating muscle fibers embedded in the stomach. Following this, for the first time, we simulate gravity-driven bolus emptying into the stomach due to density differences between ingested contents and fluid contents of the stomach. Finally, we present a case of retrograde flow of fluid from the stomach into the esophagus, resembling the phenomenon of acid reflux. This detailed computational model of the upper gastrointestinal tract provides a foundation for future models to investigate the biomechanics of acid reflux and probe various strategies for gastric bypass surgeries to address the growing problem of obesity.
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